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A23187, 98%, free acid, Thermo Scientific Chemicals
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A23187, 98%, free acid, Thermo Scientific Chemicals
A23187, 98%, free acid, Thermo Scientific Chemicals
A23187, 98%, free acid, Thermo Scientific Chemicals
Thermo Scientific Chemicals

A23187, 98%, free acid, Thermo Scientific Chemicals

A23187 (Calcimycin), CAS # 52665-69-7, is a calcium ionophore-based antibiotic.
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Catalog NumberQuantityPackaging
3280800101 mgGlass Bottle in Plastic Container
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Catalog number 328080010
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48,65
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Quantity:
1 mg
Packaging:
Glass Bottle in Plastic Container
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Price (EUR)
48,65
Online Exclusive
54,30
Save 5,65 (10%)
Each
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Chemical Identifiers
CAS52665-69-7
IUPAC Name5-(methylamino)-2-{[(2S,3S,8S,9R,11R)-3,9,11-trimethyl-8-[1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-2-yl]methyl}-1,3-benzoxazole-4-carboxylic acid
Molecular FormulaC29H37N3O6
InChI KeyHIYAVKIYRIFSCZ-CVXKHCKVSA-N
SMILESCNC1=CC=C2OC(C[C@@H]3OC4(CC[C@@H]3C)O[C@H](C(C)C(=O)C3=CC=CN3)[C@H](C)C[C@H]4C)=NC2=C1C(O)=O
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White to almost white
Appearance (Form)Solid
Infrared spectrumConforms
TLC>=97.5 %
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description


• A23187 is a polyether substance that permeabilizes cell membranes to calcium and other divalent cations


Applications
• A23187 can be used for the study of mitochondrial physiology because it acts as an uncoupling agent
• A23187 can be used to study the roles of divalent cations in cell physiology
• When bound to fluorescent calcium ions, A23187 can be useful for imaging studies

RUO – Research Use Only

Molinaro, R.; Mukherjee, T.; Flick, R.; Philpott, D.J.; Girardin, S.E. Trace levels of peptidoglycan in serum underlie the NOD-dependent cytokine response to endoplasmic reticulum stress. J Biol Chem. 2019 294(22), 9007-9015.
Takeuchi, T.; Harada, Y.; Moriyama, S.; Furuta, K.; Tanaka, S.; Miyaji, T.; Omote, H.; Moriyama, Y.; Hiasa, M. Vesicular Polyamine Transporter Mediates Vesicular Storage and Release of Polyamine from Mast Cells. J Biol Chem. 2017 292(9), 3909-3918.