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Fumonisin B1, 96%
Fumonisin, CAS # 116355-83-0, also known as Macrofusine, is a cell permeable mycotoxin that is an inhibitor of sphingosine N-acetyl transferase. | CAS: 116355-83-0 | C34H59NO15 | 721.8 g/mol
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Chemical Identifiers
CAS116355-83-0
IUPAC Name(2S)-2-(2-{[(5S,6R,7R,9R,11S,16R,18S,19S)-19-amino-6-{[(3S)-3,4-dicarboxybutanoyl]oxy}-11,16,18-trihydroxy-5,9-dimethylicosan-7-yl]oxy}-2-oxoethyl)butanedioic acid
Molecular FormulaC34H59NO15
InChI KeyUVBUBMSSQKOIBE-ZWKVXHQASA-N
SMILESCCCC[C@H](C)[C@@H](OC(=O)C[C@H](CC(O)=O)C(O)=O)[C@@H](C[C@H](C)C[C@@H](O)CCCC[C@@H](O)C[C@H](O)[C@H](C)N)OC(=O)C[C@H](CC(O)=O)C(O)=O
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Specifications
Specification Sheet
Specification SheetHPLC>=95 %
Appearance (Color)White to tan
Appearance (Form)Powder or granules or solid
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Fumonisin is a fungal metabolite that is a cell permeable mycotoxin that can halt sphingolipid biosynthesis by inhibiting sphingosine N-acetyl transferase
Applications
• It can potently inhibit sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases
• It is also a protein serine and threonine phosphatase inhibitor
• It can selectively inhibit sphingomyelin biosynthesis in neuronal cells
RUO – Research Use Only
General References:
- Stockmann-Juvala, H., et al., 2008. A review of the toxic effects and mechanisms of action of fumonisin B1. Human & experimental toxicology. 27(11), 799-809.
- Fukuda et al (1996) Inhibition of protein serine/threonine phosphatases by Fumonisin B1, a mycotoxin. Biochem.Biophys.Res.Comms. 220 160.