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Thermo Scientific Chemicals
β-Estradiol, 98%
β-Estradiol, 98%, CAS # 50-28-2, is an estrogen steroid sex hormone that regulates several biological functions including gene transcription and protein synthesis.
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| Catalog Number | Quantity | Packaging |
|---|---|---|
| 436320250 | 25g | Glass bottle |
| 436320050 | 5g | Glass bottle |
Catalog number 436320250
Price (EUR)
615,00
Each
Quantity:
25g
Packaging:
Glass bottle
Price (EUR)
615,00
Each
Chemical Identifiers
CAS50-28-2
IUPAC Name(1S,3aS,3bR,9bS,11aS)-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-1,7-diol
Molecular FormulaC18H24O2
InChI KeyVOXZDWNPVJITMN-ZBRFXRBCSA-N
SMILESC[C@]12CC[C@H]3[C@@H](CCC4=CC(O)=CC=C34)[C@@H]1CC[C@@H]2O
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Specifications
Specification Sheet
Specification SheetAppearance (Color)White to off-white
Infrared spectrumConforms
Appearance (Form)Powder
Melting point173°C to 179°C
Water=<3.5 %
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• β-Estradiol is a naturally occurring endogenous hormone in females
• It is an important steroid sex hormone involved in the regulation of several biological functions including gene transcription and protein synthesis
• This hormone is produced by the ovaries and can bind to and activate specific nuclear receptors
Applications
• β-Estradiol acts as an estrogenic hormone receptor agonist and activator of PI 3-kinase
• It shows inhibitory activity against aldehyde oxidase
• β-Estradiol presents mild anabolic and metabolic activities and increases blood coagulability in vivo experiments
• It plays a role in immune and inflammatory processes
• β-Estradiol triggers an increase in hepatic synthesis of some proteins, including sex hormone-binding globulin (SHBG), and thyroid-binding globulin (TBG), and suppresses the formation of follicle-stimulating hormone (FSH)
• This compound has been used for the in vitro maturation of bovine cumulus-oocyte complexes (COCs)
RUO – Research Use Only
Literature References
Beker, A.R.; Colenbrander, B.; Bevers, M.M. Effect of 17beta-estradiol on the in vitro maturation of bovine oocytes. Theriogenology. 2002, 58, (9), 1663-1673.
Maksura, H.; Akon, N.; Islam, M.N.; Akter, I.; Modak, A.K.; Khatun, A.; Alam, M.H.; Hashem, M.A.; Amin, M.R.; Moniruzzaman, M. Effects of estradiol on in vitro maturation of buffalo and goat oocytes. Reprod Med Biol. 2020 Sep 25;20(1):62-70.
Liu, X.; Liu, Y.; Cheng, M.; Zhang, X.; Xiao, H. A metabolomics study of the inhibitory effect of 17-beta-estradiol on osteoclast proliferation and differentiation. Mol. Biosyst. 2015, 11 (2), 635-646.
Pooley, A. E.; Luong, M.; Hussain, A.; Nathan, B. P. Neurite outgrowth promoting effect of 17-beta estradiol is mediated through estrogen receptor alpha in an olfactory epithelium culture. Brain Res. 2015, 1624, 19-27.