Doxycycline hyclate, 97%

Doxycycline hyclate, Doryx, CAS # 24390-14-5, is the hyclate salt form of the broad-spectrum antibiotic known as doxycycline.

Catalog Number	Quantity
446060050	5g

Catalog number 446060050

Price (EUR)

35,65

Online Exclusive

39,00

Save 3,35 (9%)

Quantity:

Request bulk or custom format

Price (EUR)

35,65

Online Exclusive

39,00

Save 3,35 (9%)

Chemical Identifiers

CAS24390-14-5

IUPAC Namedihydrogen bis((2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-1,2,3,4,4a,5,5a,6,12,12a-decahydrotetracene-1,3,12-trione) ethanol hydrate dichloride

Molecular FormulaC46H58Cl2N4O18

InChI KeyQDDHZFKCHWYXJF-PCLMCNLLSA-N

SMILES[H+].[H+].O.[Cl-].[Cl-].CCO.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(=O)C(=C(N)O)C(=O)[C@@]3(O)C(=O)C2=C(O)C2=C(O)C=CC=C12.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(=O)C(=C(N)O)C(=O)[C@@]3(O)C(=O)C2=C(O)C2=C(O)C=CC=C12

Specifications

HPLC>=96.0 %

Appearance (Form)Powder

Water1.4 to 2.8 %

Infrared spectrumConforms

Appearance (Color)White to yellow

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

Doxycycline hyclate is a broad-spectrum bacteriostatic antibiotic of the tetracycline class
Doxycycline inhibits bacterial growth by preventing polypeptide formation via inhibition of at least one ribosomal subunit
Known to reversibly bind the 30S ribosomal subunit and inhibit formation of the aminoacyl-tRNA/mRNA-ribosome complex
Inhibits matrix metalloproteinases in many microorganisms

Applications

Effective against the bacteria that cause Lyme disease, chlamydia, rickettsia and mycoplasma; suitable for antibiotic resistance testing and study of cellular mechanisms
Intended for laboratory use only

RUO – Research Use Only

Literature references: Adrian, J.; Fernández, F.; Sánchez-Baeza, F.; Marco, M. P. Preparation of antibodies and development of an enzyme-linked immunosorbent assay (ELISA) for the determination of doxycycline antibiotic in milk samples. J Agric Food Chem. 2012, 60(15), 3837-46.Aleksic, T.; Baumann, B., Wagner, M.; Adler, G.; Wirth, T.; Weber, C. K. Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2. Gut. 2007, 56(2), 227-36. Moore, A. L.; desJardins-Park, H. E.; Duoto, B. A.; Mascharak, S.; Murphy, M. P.; Irizarry, D. M.; Foster, D. S.; Jones, R. E.; Barnes, L. A.; Marshall, C. D; Ransom, R. C.; Wernig, G.; Longaker, M. T. Doxycycline Reduces Scar Thickness and Improves Collagen Architecture. Ann Surg. 2020, 272(1),183-193. Doxycycline host-directed therapy in human pulmonary tuberculosis.Miow Q. H.; Vallejo A. F.; Wang Y; Hong J. M.; Bai C., Teo F. S.; Wang A. D.; Loh H. R.; Tan T. Z.; Ding Y., She H. W.; Gan S. H.; Paton N. I.; Lum J.; Tay A.; Chee C. B.; Tambyah P. A.; Polak M. E.; Wang Y. T.; Singhal A.; Elkington P. T.; Friedland J. S.; Ong C. W. J Clin Invest. 2021 Aug 2;131(15):e141895. doi: 10.1172/JCI141895.