Colistin sulfate salt

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Thermo Scientific Chemicals

Colistin sulfate salt

Name: Colistin sulfate salt
SKU: 455390010
Price: 168.65 EUR

Colistin Sulfate salt (2:5), CAS # 1264-72-8, (synonym: Polymyxin E Complex), is a complex mixture of antibiotics, with Colistin A and B being the primary components. It has anti-bacterial activity against Gram-positive and Gram-negative bacteria and may also be used as a neuromuscular blocker.

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Catalog Number	Quantity
455390010	1 g
455392500	250 mg

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Catalog number 455390010

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Price (EUR)

168,65

キャンペーン価格

187,00

Save 18,35 (10%)

Each

Add to cart

Chemical Identifiers

CAS1264-72-8

IUPAC NameN-[(1S)-3-amino-1-{[(1S,2R)-1-{[(1S)-3-amino-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl]carbamoyl}-2-hydroxypropyl]carbamoyl}propyl]-6-methyloctanamide; sulfuric acid

Molecular FormulaC53H102N16O17S

InChI KeyZJIWRHLZXQPFAD-LRYSGCCDSA-N

SMILESOS(O)(=O)=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O

Specifications

Specification Sheet

Additional infoMay contain up to 15 % water

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description
• Colistin Sulfate salt is a stable, cationic, water-soluble, white powder composed of over 30 components
• Originally isolated from B. polymyxa, it inhibits the growth of the Gram-negative (e.g. E. coli, P. aeruginosa, P. fluorescens, and S. enterica), and Gram-positive bacteria (e.g. L. lactis, P. polymyxa, P. acidilactici, and S. aureus) by permeabilizing the bacterial cell membrane

Applications
• Colistin Sulfate has potent anti-endotoxin activity rendered through its ability to bind lippopolysaccharides that make up bacterial endotoxins
• This compound is often used in the management of multi-drug resistant Gram-negative infections

RUO – Research Use Only

Literature References:
Falagas, M. E.; Kasiakou, S. K.; Saravolatz, L. D. Colistin: The Revival of Polymyxins for the Management of Multidrug-Resistant Gram-Negative Bacterial Infections Clinical Infectious Diseases. 2005, 40 (9), 1333–1341.
Suzuki, T.; Inouye, H.; Fujikawa, K.; et al. Studies on the chemical structure of colistin. I. Fractionation, molecular weight determination, amino acid and fatty acid composition. J. Biochem. 1963, 54(1), 25-33.
Naghmouchi, K.; Hammami, R.; Fliss, I.; et al. Colistin A and colistin B among inhibitory substances of Paenibacillus polymyxa JB05-01-1. Arch. Microbiol. 2012, 194(5), 363-370.
Mitsugui, C.S.; Tognim, M.C.B.; Cardoso, C.L.; et al. In vitro activity of polymyxins in combination with β-lactams against clinical strains of Pseudomonas aeruginosa. Int. J. Antimicrob. 2011, 38(5), 447-450.