Gabapentin, 98%

Name: Gabapentin, 98%
SKU: 458020050

Gabapentin, CAS # 60142-96-3, is a synthetic analogue of the neurotransmitter gamma-aminobutyric acid with anticonvulsant and analgesic activities. | CAS: 60142-96-3 | C₉H₁₇NO₂ | 171.24 g/mol

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Catalog number 458020050

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5 g

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Chemical Identifiers

CAS60142-96-3

IUPAC Name2-[1-(aminomethyl)cyclohexyl]acetic acid

Molecular FormulaC9H17NO2

InChI KeyUGJMXCAKCUNAIE-UHFFFAOYSA-N

SMILESNCC1(CC(O)=O)CCCCC1

Specifications

Specification Sheet

Appearance (Form)Powder

Appearance (Color)White to almost white

Infrared spectrumConforms

Melting point162°C to 168°C

Titration with HClO4>=97.5 %

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Gabapentin is a water-soluble GABA analog with anticonvulsant and analgesic activities
The exact mechanism of action is unknown but it has been described that this compound inhibits excitatory neuron activity by interacting with voltage-gated calcium channels in cortical neurons

Application

Gabapentin has been used as the α2δ-ligand to examine whether the allyl isothiocyanate (AITC) sensitized thermal aversion assay might be useful as a screening method for the identification of presumptive analgesics

RUO – Research Use Only

General References:

Curtright, A.; Rosser, M.; Goh, S.; Keown, B.; Wagner, E.; Sharifi, J.; Raible, D.W.; Dhaka, A. Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery. PLoS One. 2015, 14, 10, (1), e0116766.
Yasaei, R.; Katta, S.; Saadabadi, A. Gabapentin. [Updated 2021 Dec 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022.