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Voriconazole, 98%, Thermo Scientific Chemicals
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Voriconazole, 98%, Thermo Scientific Chemicals
Voriconazole, 98%, Thermo Scientific Chemicals
Voriconazole, 98%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Voriconazole, 98%, Thermo Scientific Chemicals

Voriconazole, CAS # 137234-62-9, is an antifungalagent that acts by inhibition of sterol biosynthesis.
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Catalog NumberQuantity
4586700101 g
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Catalog number 458670010
Price (EUR)
139,65
온라인 행사
155,00
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Quantity:
1 g
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Price (EUR)
139,65
온라인 행사
155,00
Save 15,35 (10%)
Each
Add to cart
Chemical Identifiers
CAS137234-62-9
IUPAC Name(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
Molecular FormulaC16H14F3N5O
InChI KeyBCEHBSKCWLPMDN-MGPLVRAMSA-N
SMILESC[C@@H](C1=NC=NC=C1F)[C@](O)(CN1C=NC=N1)C1=CC=C(F)C=C1F
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SpecificationsSpecification SheetSpecification Sheet
Infrared spectrumConforms
Loss on drying=<0.5 %
HPLC>=97.5 %
Appearance (Color)White to off-white
Appearance (Form)Crystalline powder
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
Voriconazole is an antifungal compound that has activity against a wide variety of fungal species including Aspergillus and Candida
Voriconazole blocks sterol biosynthesis in Candida species through inhibition of CYP450-dependent 14-alpha sterol demethylase
It depletes the presence of ergosterol in the fungal cell membrane, which can lead to death or growth inhibition, depending on the organism
Applications
Voriconazole may be used in laboratory studies of drug safety, pharmacokinetics, and mechanism of action
Voriconazole has been used to inhibit CYP46A1 enzymatic activity in mouse neuroblasts
Voriconazole inhibits 24(S)-hydroxycholesterol in an ex vivo rat glaucoma model
RUO – Research Use Only
Literature references
Kappe, R. Antifungal activity of the new azole UK-109, 496 (voriconazole). Mycoses. 1999, 42, 2:83-6
Sanati, H.; Belanger, P.; Fratti, R.; Ghannoum, M. A new triazole, voriconazole (UK-109,496), blocks sterol biosynthesis in Candida albicans and Candida krusei. Antimicrob Agents Chemother. 1997 Nov;41(11), 2492-6.
Zhao, Y.; Hu, D.; Wang, R.; Sun, X.; Ropelewski, P.; Hubler, Z.; Lundberg, K.; Wang, Q.; Adams, D.J.; Xu, R.; Qi, X. ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models. Nat Commun. 2022, 13(1), 1121.
Ishikawa, M.; Yoshitomi, T.; Covey, D.F.; Zorumski, C.F.; Izumi, Y. Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model. Sci Rep. 2018, 8(1), 12851.