Rifabutin, 98%, Thermo Scientific Chemicals

Rifabutin, CAS # 72559-06-09, is a broad-spectrum antibiotic with activity against mycobacteria, gram-positive and gram-negative bacteria.

Catalog Number	Quantity
461210050	5 g

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Catalog number 461210050

Price (EUR)

508,00

Quantity:

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Price (EUR)

508,00

Chemical Identifiers

CAS72559-06-9

IUPAC Name(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-(2-methylpropyl)-6,23,32-trioxo-8,33-dioxa-24,27,29-triazaspiro[pentacyclo[23.6.1.1⁴,⁷.0⁵,³¹.0²⁶,³⁰]tritriacontane-28,4'-piperidin]-1,3,5(31),9,19,21,25,29-octaen-13-yl acetate

Molecular FormulaC46H62N4O11

InChI KeyATEBXHFBFRCZMA-VXTBVIBXSA-N

SMILESCO[C@H]1C=CO[C@@]2(C)OC3=C(C)C(O)=C4C(=O)C(NC(=O)C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)=C1NC5(CCN(CC(C)C)CC5)N=C1C4=C3C2=O

Specifications

Water=<2.5 %

Appearance (Form)Powder

Infrared spectrumConforms

HPLC>=97.5 %

Appearance (Color)Red to violet

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Rifabutin is a compound with antibacterial activity most commonly used against Mycobacterium tuberculosis
Rifabutin is a derivative of Rifamycin S that acts through blocking RNA polymerase subunit beta (RpoB)
Rifabutin is an inducer as well as a substrate of CYP3A, a cytochrome P450 enzyme

Applications

Rifabutin may be used in pharmacokinetic laboratory studies and high-throughput drug screens
May be used in laboratory studies to determine drug resistance mutations present in Mycobacterium tuberculosis strains

RUO – Research Use Only

General References:

Jamieson, F.B.; Guthrie, J.L.; Neemuchwala, A.; Lastovetska, O.; Melano, R.G.; Mehaffy, C. Profiling of rpoB mutations and MICs for rifampin and rifabutin in Mycobacterium tuberculosis. J Clin Microbiol. 2014, 52(6), 2157-62.
Cavusoglu, C.; Karaca-Derici, Y.; Bilgic, A. In-vitro activity of rifabutin against rifampicin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations. Clin Microbiol Infect. 2004, 10(7), 662-5.
Doub, J.B.; Heil, E.L.; Ntem-Mensah, A.; Neeley, R.; Ching, P.R. Rifabutin Use in Staphylococcus Biofilm Infections: A Case Series. Antibiotics (Basel). 2020, 9(6), 326.
Sousa, M.; Pozniak, A.; Boffito, M. Pharmacokinetics and pharmacodynamics of drug interactions involving rifampicin, rifabutin and antimalarial drugs, Journal of Antimicrobial Chemotherapy, Volume 62, Issue 5, 2008, Pages 872–878.