Dimethyl aminoterephthalate, 99%
Dimethyl aminoterephthalate, 99%
Dimethyl aminoterephthalate, 99%
Dimethyl aminoterephthalate, 99%
Thermo Scientific Chemicals

Dimethyl aminoterephthalate, 99%

CAS: 5372-81-6 | C10H11NO4 | 209.201 g/mol
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Catalog number A10567.30
also known as A10567-30
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Chemical Identifiers
CAS5372-81-6
IUPAC Name1,4-dimethyl 2-aminobenzene-1,4-dicarboxylate
Molecular FormulaC10H11NO4
InChI KeyDSSKDXUDARIMTR-UHFFFAOYSA-N
SMILESCOC(=O)C1=CC=C(C(=O)OC)C(N)=C1
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)Cream to yellow to green to brown
FormPowder
Melting Point (clear melt)129.0-137.0?C
Assay (GC)≥98.5%
Dimethyl aminoterephthalate is used in the preparation of imidazotetrazinones as probes for the action of temozolomide. It is also used to prepare aminoquinazolines with neurokinin-2 receptor antagonist activity.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Dimethyl aminoterephthalate is used in the preparation of imidazotetrazinones as probes for the action of temozolomide. It is also used to prepare aminoquinazolines with neurokinin-2 receptor antagonist activity.

Solubility
Insoluble in water.

Notes
Incompatible with strong oxidizing agents.
RUO – Research Use Only

General References:

  1. Borbone, F.; Tarallo, O.; Roviello, V.; Caruso, U.; Pirozzi, B.; Roviello, A. Novel rigid rod polymers from a thermal cyclization reaction. Eur. Polym. J. 2015, 63, 80-89.
  2. Samokhvalov, A. Adsorption on Mesoporous Metal-Organic Frameworks in Solution: Aromatic and Heterocyclic Compounds. Chem. Eur. J. 2015, 21 (47), 16726-16742.