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Isopropylidene malonate, 97%, Thermo Scientific Chemicals
Catalog number: A15603.36
500 g, Each
Thermo Scientific Chemicals
Isopropylidene malonate, 97%, Thermo Scientific Chemicals
Catalog number: A15603.36
500 g, Each
Quantity
Catalog number: A15603.36
also known as A15603-36
Price (EUR)
387,15 Online price
435,00
Each
Quantity
-
Chemical Identifiers
CAS
2033-24-1
IUPAC Name
2,2-dimethyl-1,3-dioxane-4,6-dione
Molecular Formula
C6H8O4
InChI Key
GXHFUVWIGNLZSC-UHFFFAOYSA-N
SMILES
CC1(C)OC(=O)CC(=O)O1
Specifications
Specification SheetAppearance (Color)
White to pale brown
Identification (FTIR)
Conforms
Assay (Aqueous acid-base Titration)
≥96.0% to ≤104.0%
Melting Point (clear melt)
88-97°C
Form
Crystals or crystalline powder
Description
Isopropylidene malonate is an important reagent in synthetic chemistry and involved in the formation of new C-C bonds, rings, amides, esters, and acids. The presence of carbonyl groups at C-4 and C-6 positions favors the alkylation and acylation reactions due to its acidic nature. It is also employed as an antimicrobial agent. It is used in the preparation of 4-pyridyl-substituted heterocycles, 2-substituted indoles, isofraxidin and macrocyclic beta-keto lactones. Further, it is involved in the Knoevenagel condensation reaction with aldehydes.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Isopropylidene malonate is an important reagent in synthetic chemistry and involved in the formation of new C-C bonds, rings, amides, esters, and acids. The presence of carbonyl groups at C-4 and C-6 positions favors the alkylation and acylation reactions due to its acidic nature. It is also employed as an antimicrobial agent. It is used in the preparation of 4-pyridyl-substituted heterocycles, 2-substituted indoles, isofraxidin and macrocyclic beta-keto lactones. Further, it is involved in the Knoevenagel condensation reaction with aldehydes.
Solubility
Soluble in water. Slightly soluble in ethanol and chloroform.
Notes
Store in a cool place. Incompatible with strong oxidizing agents.
Isopropylidene malonate is an important reagent in synthetic chemistry and involved in the formation of new C-C bonds, rings, amides, esters, and acids. The presence of carbonyl groups at C-4 and C-6 positions favors the alkylation and acylation reactions due to its acidic nature. It is also employed as an antimicrobial agent. It is used in the preparation of 4-pyridyl-substituted heterocycles, 2-substituted indoles, isofraxidin and macrocyclic beta-keto lactones. Further, it is involved in the Knoevenagel condensation reaction with aldehydes.
Solubility
Soluble in water. Slightly soluble in ethanol and chloroform.
Notes
Store in a cool place. Incompatible with strong oxidizing agents.
RUO – Research Use Only
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Safety and Handling
Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Skin Corrosion/Irritation
Category 2
Acute aquatic toxicity
Category 1
Chronic aquatic toxicity
Category 2
Label Elements
Signal Word
Warning
Hazard Statements
H315 - Causes skin irritation
H400 - Very toxic to aquatic life
H411 - Toxic to aquatic life with long lasting effects
Precautionary Statements
P280 - Wear protective gloves/protective clothing
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P332 + P313 - If skin irritation occurs: Get medical advice/attention