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Pyridinium p-toluenesulfonate, 98+%

Name: Pyridinium p-toluenesulfonate, 98+%
SKU: A15708.22
Price: 279.00 EUR

CAS: 24057-28-1 | C₁₂H₁₃NO₃S

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Catalog number A15708.22

also known as A15708-22

Price (EUR)

279,00

Each

Quantity:

100 g

Request bulk or custom format

Price (EUR)

279,00

Each

Chemical Identifiers

CAS24057-28-1

IUPAC Name4-methylbenzene-1-sulfonic acid; pyridine

Molecular FormulaC12H13NO3S

InChI KeyZDYVRSLAEXCVBX-UHFFFAOYSA-N

SMILESC1=CC=NC=C1.CC1=CC=C(C=C1)S(O)(=O)=O

Specifications

Specification Sheet

Formcrystalline powder

Identification (FTIR)Conforms

Appearance (Color)White to cream

Assay (Aqueous acid-base Titration)> 98.0%

Water Content (Karl Fischer Titration)< 1.0%

Pyridinium p-Toluenesulfate is used in the synthesis of a subdomain of the cytochrome P450 BM3 enzyme, for use in screening systems for drug candidates. Efficient catalyst for preparing tetrahydropyranyl ethers.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Pyridinium p-Toluenesulfate is used in the synthesis of a subdomain of the cytochrome P450 BM3 enzyme, for use in screening systems for drug candidates. Efficient catalyst for preparing tetrahydropyranyl ethers.

Solubility
Soluble in water (partly), ethanol, acetone, dichloromethane, chloroform, methanol and dimethyl sulfoxide.

Notes
Moisture Sensitive. Store in a tightly closed container. Store in a cool, dry, well-ventilated. Store protected from moisture.

RUO – Research Use Only

General References:

Masaaki Miyashita; Akira Yoshikoshi; Paul A. Grieco. Pyridinium p-toluenesulfonate. A mild and efficient catalyst for the tetrahydropyranylation of alcohols. J. Org. Chem. 1977, 42 (23), 3772-3774.
Takeshi Matsukawa, Yoshihiro Mineno; Toru Odani; Shuji Okadab; Tetsuo Taniuchic;Synthesis and terahertz-wave generation of mixed crystals composed of 1-methyl-4-{2-[4-(dimethylamino)phenyl]ethenyl}pyridinium p-toluenesulfonate and p-chlorobenzenesulfonate. Journal of Crystal Growth. 2007, 299 (22), 344-348.
Mild catalyst for the formation of THP derivatives of alcohols superior to p-toluenesulfonic acid, where acid-sensitive functionality is present. Similarly, the reagent has been used for deprotection of THP ethers in ethanol: J. Org. Chem., 42. 3772 (1977).
This application has been extended to other acetalization or trans-acetalization reactions, where more acidic conditions are undesirable: Synthesis, 724 (1979).
For use in cleavage of TBDMS protecting groups, see: J. Chem. Soc. Perkin 1, 169 (1993).