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2,3,5,6-Tetramethylpyrazine, 98+%
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2,3,5,6-Tetramethylpyrazine, 98+%
2,3,5,6-Tetramethylpyrazine, 98+%
2,3,5,6-Tetramethylpyrazine, 98+%
Thermo Scientific Chemicals

2,3,5,6-Tetramethylpyrazine, 98+%

CAS: 1124-11-4 | C8H12N2 | 136.198 g/mol
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Catalog number A18279.14
also known as A18279-14
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Quantity:
25 g
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Price (EUR)
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Chemical Identifiers
CAS1124-11-4
IUPAC Nametetramethylpyrazine
Molecular FormulaC8H12N2
InChI KeyFINHMKGKINIASC-UHFFFAOYSA-N
SMILESCC1=NC(C)=C(C)N=C1C
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SpecificationsSpecification SheetSpecification Sheet
Assay (GC)≥98.0%
Appearance (Color)White
FormCrystals or powder or crystalline powder
Melting Point83.5-89.5?C
2,3,5,6-Tetramethylpyrazine is a flavor ingredient of tobacco. It forms cocrystal with 4-hydroxybenzoic acid which exhibits supramolecular synthon polymorphism.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2,3,5,6-Tetramethylpyrazine is a flavor ingredient of tobacco. It forms cocrystal with 4-hydroxybenzoic acid which exhibits supramolecular synthon polymorphism.

Solubility
Soluble in water (4 g/L at 20°C).

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
RUO – Research Use Only

General References:

  1. B.R.Sreekanth; Peddy Vishweshwar; K.Vyas. Supramolecular synthon polymorphism in 2 : 1 co-crystal of 4-hydroxybenzoic acid and 2,3,5,6-tetramethylpyrazine. Chemical Communications. 2007, 23,2375-2377.
  2. Wei Wu; Xiao Yu; Xiao-Ping Luo; Shu-Hua Yang; Dong Zheng. Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway. Behavioural Brain Research. 2013, 253,212-216.
  3. Has been used as a component of a buffer to control the acid-catalyzed ring-opening of epoxides: J. Chem. Soc., Perkin 2, 1309 (1972).