Thermo Scientific™

Stellar™ Mass Spectrometer

Accelerate biomarker verification more efficiently, confidently, and at lower cost with breakthroughs in sensitivity, specificity and throughput at scale.

Catalog Number	Type
B51003515	Mass spectrometer

Catalog number B51003515

Price (EUR)

Type:

Mass spectrometer

Transition biomarker candidates from discovery to validation more efficiently, confidently, and at lower cost with the Thermo Scientific™ Stellar™ mass spectrometer. With breakthroughs in sensitivity, specificity, and throughput at scale, you can verify more putative biomarkers in less time and with less effort. Revolutionary technology delivers rapid full scan MSⁿ acquisition with single ion sensitivity improving limits of quantitation (LOQ) 10x when targeting 5x more analytes. Novel software automates multi-analyte method creation, dynamic instrument control for unmatched productivity.

The Stellar mass spectrometer drives biomarker discovery to validation at unprecedented scale by combining advanced quadrupole technology and the Hyper-fast Dual Pressure Linear ion trap mass analyzer acquiring sensitive and reproducible data at speeds up to 140 Hz. The PRM Conductor software leverages discovery data to rapidly and confidently build highly multiplexed targeted quantitative methods as well as manage data acquisition to further increase laboratory productivity and capacity by almost 80% compared to existing workflows. Primary benefits of the Stellar MS include:

Expanded scale
Higher sensitivity
Greater specificity
Massive throughput
Unrivaled productivity

Specifications

Dimensions (D x W x H)33 x 30 x 27 in.

For Use With (Application)Pharmaceutical, Clinical Research, Forensic Toxicology, Proteomics, Metabolomics, and Biopharmaceutical

For Use With (Equipment)OptaMax Plus Ion Source, FAIMS Pro Duo interface, EASYSpray Series, Nanospray Flex Series

Green FeaturesACT Ecolabel (Gold)

Polarity Switching5 milliseconds

Mass RangeFull Scan Mode: 5 to 2000 m/z and MSⁿ mode: 20 to 2000 m/z

TypeMass spectrometer

Unit SizeEach

Frequently asked questions (FAQs)

What molecular classes and sample types does Stellar MS handle?

Thermo Scientific Stellar MS supports a broad and diverse set of analytes and sample types, from small molecules all the way up to peptides and proteins. The Stellar MS system is specifically designed to cover biomarker panels that include small molecules, including steroids and drug-metabolites, to large molecules, including peptides and proteins.

For sensitivity, compound coverage, and throughput, how does Stellar MS compare to older instruments or competitors?

The Thermo Scientific Stellar MS offers approximately 10 times the quantitative sensitivity compared to traditional technologies and can analyze five times more compounds in proteomics, metabolomics, and lipidomics workflows. It supports rapid method development (workflows created in days instead of weeks) and high throughput UHPLC integration (such as with the Vanquish Neo system) to help reduce total time-to-result.

Does the Stellar MS support translational or clinical-omics workflows and what are the advantages over general-purpose HRAM systems?

The Thermo Scientific Stellar MS helps accelerate translational research—its combination of fast throughput, high sensitivity, and ease-of-use positions it for verification of proteins, metabolites, and lipids in clinical-research workflows. While many HRAM instruments focus on discovery (broad coverage), Stellar is a “verification-class” instrument—meaning it excels in targeted, high-throughput, high-confidence quantitation, which differentiates it from generalized HRAM systems that may offer breadth but lower throughput in targeted analyses.

For high-throughput targeted quantitation, how does the Stellar MS compare to traditional triple quadrupole instruments?

The Thermo Scientific Stellar MS is combines the quantitative performance of a premier quadrupole-quadrupole mass spectrometer with the extended analytical capabilities of a dual-pressure linear ion-trap MS. It delivers up to ~10× better quantitative sensitivity and can analyze ~5× more compounds versus traditional workflows for targeted proteomics, metabolomics, lipidomics, toxicology, and bio analysis. This means that laboratories seeking to move from discovery to validation workflows (e.g., biomarker verification) can gain significantly greater throughput and sensitivity with the Stellar MS.