Orbitrap™ Excedion™ Pro Mass Spectrometers

Thermo Scientific™

Orbitrap™ Excedion™ Pro Mass Spectrometers

Name: Orbitrap™ Excedion™ Pro Mass Spectrometers
SKU: BRE725570

Discover Thermo Scientific™ Orbitrap™ Excedion™ Pro Mass Spectrometers - next generation hybrid mass spectrometers with exceptional performance for proteins, peptides, and small molecules analysis.

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Catalog Number	Model
BRE725570	Orbitrap Excedion Pro Mass Spectrometer with EASY-ETD ion source for metabolomics, lipidomics, proteomics, and structural biology
BRE725571	Orbitrap Excedion Pro BioPharma Mass Spectrometer
BRE0065446	EASY-ETD option available at factory install or field upgrade for Orbitrap Excedion Pro Mass Spectrometers.
BRE725572	Orbitrap Excedion Pro Mass Spectrometer for metabolomics, lipidomics, proteomics, and structural biology
BRE0065480	Field upgrade Electron Transfer Dissociation (ETD)

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Catalog number BRE725570

Price (EUR)

Model:

Orbitrap Excedion Pro Mass Spectrometer with EASY-ETD ion source for metabolomics, lipidomics, proteomics, and structural biology

Enhance your research and achieve groundbreaking discoveries with Orbitrap Excedion Pro Hybrid Mass Spectrometers, with models to meet your specific needs.

The Orbitrap Excedion Pro BioPharma Mass Spectrometer delivers extended capabilities for biopharma characterization applications and higher order structural biology with mass detection up to m/z 12,000. In addition, optional fast and sensitive Electron Transfer Dissociation (ETD) and Electron-Transfer/Higher-Energy Collision Dissociation (EThcD) alternative fragmentation can be field or factory installed.

The core model Orbitrap Excedion Pro Mass Spectrometer offers exceptional performance for proteomics with advanced capabilities for sensitive non-targeted metabolomics and lipidomics analysis. Optional fast and sensitive ETD/EThcD can be factory or field installed for proteomics applications.

Elevate your biopharma characterization

Detect low abundant Asp/IsoAsp isomerization
Detailed structural elucidation: Discern Leucin and Isoleucin isobaric masses with great confidence
Top-up the sequence coverage in middle-down analysis with fast radical driven fragmentation

Innovate higher-order structure characterization of biomolecules

ETD fragmentation option enables near single residue resolution in bottom-up and top-down Hydrogen-Deuterium Exchange (HDX) analysis with high sensitivity for alternative fragmentation ETD in ion routing multipole and combination of EThcD in the ion routing multipole for detection in the Orbitrap mass analyzer
Fast and sensitive ETD reaction of precursor ion with fluoranthene radical anions (m/z 202) injection into the IRM to generate a series of c/z-fragment ions. EThcD fragmentation enabled by reaccelerating ETD fragment ions into IRM for HCD fragmentation
HDX-based MS offers a comprehensive and novel toolset for the analysis of protein conformation, conformation dynamics, and protein-protein interactions

Exceed in proteomics research

Accurate quantification with extended dynamic range
Hybrid-DIA
Deep proteome coverage
PTMs analysis with ETD fragmentation
Immunopeptidomics with EThcD fragmentation

Discovery in metabolomics research

Increased sensitivity up to 10x compound dependent
Enhanced Dynamic Range (eDR)
Increased unknown annotations

Simultaneously measure multiple parameters within a single experiment

Up to 20 precursor ions per scan

Specifications

Detection Limits

Full Scan: < 1.5 fg reserpine on column
MS2: < 1.5 fg reserpine on column
SIM: < 0.8 fg reserpine on column

Dimensions (D x W x H)29.8 x 21 x 27.6 in. (758 x 535 x 703 mm)

Dynamic RangeUp to 5 orders of magnitude intrascan

Fragmentation

Higher Collisional Dissociation (HCD) for b/y ion fragmentation is included as standard.
Electron Transfer Dissociation (ETD) for c/z ion fragmentation is factory installed.

Mass Accuracy

1-point calibration for <3 ppm RMS drift over at least 4 weeks*
Internal lock mass calibration for <1 ppm RMS drift over 24 hours*
EASY-IC for <1 ppm RMS drift for at least 5 days*

*Under defined conditions

Model

Orbitrap Excedion Pro Mass Spectrometer with EASY-ETD ion source for metabolomics, lipidomics, proteomics, and structural biology

MultiplexingUp to 20 precursor ions per scan

Max. ResolutionUp to 480,000 (FWHM) at 200 m/z

TypeOrbitrap LC-MS

Unit SizeEach

Frequently asked questions (FAQs)

What quantitative and qualitative data quality improvements does the Orbitrap Excedion Pro MS deliver?

The Thermo Scientific Orbitrap Excedion Pro MS brings qualitative improvements via richer fragmentation (ETD/EThcD) enabling complementary fragment ion types (b/y + c/z), which improves sequence coverage, discrimination of isobaric residues (e.g., leucine/isoleucine), and structural elucidation (e.g., PTMs, isoAsp modifications).

On the quantitative side, the enhanced dynamic-range mode (eDR) allows simultaneous detection of both high- and low-abundance analytes without saturation or loss of low peaks, which improves data accuracy and reproducibility in complex matrices.

The improved ion-transfer optics and optimized front end reduce losses of labile species and improve sensitivity (critical for low-input workflows).

What differentiates Orbitrap Excedion Pro MS from conventional HRAM instruments?

The Thermo Scientific Orbitrap Excedion Pro MS offers advanced fragmentation options and acquisition workflows: for example, optional Electron Transfer Dissociation (ETD) and Electron-Transfer/Higher-Energy Collision Dissociation (EThcD) in a benchtop hybrid MS system, enabling rich fragmentation of peptides, proteins, and labile molecules. The system supports Hybrid-DIA (combining discovery-mode DIA with targeted sensitivity), as well as “Turbo TMT” modes optimized for high-plex TMT experiments.

Does the Orbitrap Excedion Pro MS support small-molecule (metabolomics/lipidomics) and large-biomolecule (proteomics/biopharma) workflows?

For small molecules, the Thermo Scientific Orbitrap Excedion Pro MS excels in high sensitivity and low-in-source fragmentation, helping enable discovery of more unknowns. For large biomolecules and biopharma, the BioPharma edition supports extended mass ranges (up to m/z ~12,000) and offers advanced fragmentation (ETD/EThcD) workflows for intact-protein and post-translational-modification (PTM) characterization. The Orbitrap Excedion Pro MS is a versatile hybrid MS platform suitable for metabolomics, lipidomics, proteomics, structural biology, and biopharmaceutical characterization.