Thermo Scientific™

Orbitrap Astral Mass Spectrometer

Name: Orbitrap Astral Mass Spectrometer
SKU: BRE725600

Rethink what is possible for discovery and translational research. Faster throughput, deeper coverage, and higher sensitivity with accurate and precise quantitation empower you to accomplish your aspirations.

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Catalog Number	Mass Range	Type
BRE725600	40 to 6000 m/z	Orbitrap Astral LC-MS
BRE725660	40 to 8000 m/z	Orbitrap Astral LC-MS

2 Options

Catalog number BRE725600

Price (EUR)

Mass Range:

40 to 6000 m/z

Type:

Orbitrap Astral LC-MS

Realize the promise of proteomics at scale to better understand biology and disease mechanisms with the novel technology of the Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer. Expect whole proteome coverage at a depth of 12,000 proteins in an hour, the sensitivity to accurately and precisely quantify over 3,000 proteins from 80 single cells in a day, and the throughput to analyze over a million protein groups across 180 samples in a day. These groundbreaking capabilities empower you to comprehend the dynamic, temporal, and spatial complexity of biology.

Rethink what is possible.

Faster throughput

Identify over 8,000 proteins with an 8-minute injection-to-injection cycle

Deeper coverage

Unlock near whole-proteome depth of coverage with the identification of 12,000 proteins in 1 hour from a single-shot experiment

Higher sensitivity

Increase throughput and depth of coverage with higher sensitivity by identifying over 5,000 proteins from 250 pg of HeLa at a rate of 80 samples per day

Accurate and precise quantitation

Achieve accurate and precise quantitation with a large dynamic range for Label-Free Quantitation (LFQ) using Data-Independent Acquisition (DIA) and achieve faster throughput and deeper coverage with multiplexed quantitation using Tandem Mass Tags (TMT)

Specifications

Dimensions (D x W x H)185 x 96 x 140 cm

Dynamic Range>5000 within a single scan

Mass Accuracy

< 3 ppm RMS with external calibration, < 1 ppm RMS with internal calibration

Mass Resolution

Up to 480,000 at m/z 200

Scan RatesUp to 200 Hz

Weight (Metric)680 kg

Mass Range40 to 6000 m/z

TypeOrbitrap Astral LC-MS

Unit SizeEach

Frequently asked questions (FAQs)

What sensitivity or low-input sample performance advantages do the Orbitrap Astral MS and Orbitrap Astral Zoom MS systems provide?

The Thermo Scientific Orbitrap Astral MS introduces improved front-end ion optics (e.g., high-capacity ion transfer tube, electrodynamic ion funnel) and a novel Astral analyzer, enabling increased ion flux and lower detection limits. In the Orbitrap Astral Zoom MS, additional hardware features such as the “Bent Trap” pre-accumulation, “Low-Input Mode,” and enhanced duty cycle further improve sensitivity—supporting applications which include single-cell proteomics and low-material immunopeptidomics.

What mass-range is available on the Orbitrap Astral and Orbitrap Astral Zoom and what is the range of application coverage?

For both Thermo Scientific Orbitrap Astral Mass Spectrometers, the standard mass-range is m/z 40–6000 (for the 6000 version) and optionally m/z 40–8000 when a BioPharma option is selected. This extended range and flexibility supports workflows for protein profiling up to intact-protein/top-down biotherapeutic characterization—offering broader application coverage than many dedicated single-technique MS systems.

How does scan-rate and throughput on the Orbitrap Astral and Orbitrap Astral Zoom systems compare to legacy HRAM instruments?

The Thermo Scientific Orbitrap Astral MS features MS² acquisition rates up to 200 Hz with the Astral analyzer. The Astral Zoom MS advances this further, offering up to ~270 Hz MS² scan rates, enabling much higher sample throughput—e.g., processing ~300 samples per day in proteomics workflows. These improvements translate into faster gradient runs, more MS² events per chromatographic peak, and higher throughput than many previous generation HRAM systems.