Human Dendritic Cell Cytokine Package, PeproTech®

The Human Dendritic Cell Cytokine Package contains IL-4 and GM-CSF, key components required for the culturing of human dendritic cells. Recombinant human IL-4 is an essential cytokine used in the differentiation and maturation of human dendritic cell in vitro. The IL-4 protein, specifically the recombinant IL-4, promotes the development of dendritic cells from precursor cells such as monocytes. Human IL-4 acts synergistically with other factors, including GM-CSF (Granulocyte-Macrophage Colony Stimulating Factor), to drive the differentiation process. Typically, monocytes are cultured in the presence of recombinant IL-4 and GM-CSF to yield immature dendritic cells, which can then be futher matured by additional stimuli.

The package contains the following two vials:

• 100 μg Human IL-4 (Cat. No. 200-04-100UG)
• 100 μg Human GM-CSF (Cat. No. 300-03-100UG)

Human IL-4 protein is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. Produced by mast cells, T cells, and bone marrow stromal cells, Human IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells.

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells.