Hydrocortisone, 98%

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Hydrocortisone, 98%

Name: Hydrocortisone, 98%
SKU: 352450050
Price: 144.00 EUR

Hydrocortisone, CAS # 50-23-7, is the pharmaceutical formulation of the hormone, cortisol, and is commonly administered as an immunosuppressive drug.

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Catalog Number	Quantity	Packaging
352450050	5g	Glass bottle
352450010	1g	Glass bottle
352450250	25g	Glass bottle

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Catalog number 352450050

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Chemical Identifiers

CAS50-23-7

IUPAC Name(1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-dihydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one

Molecular FormulaC21H30O5

InChI KeyJYGXADMDTFJGBT-VWUMJDOOSA-N

SMILESC[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO

Specifications

Specification Sheet

Appearance (Form)Powder

Infrared spectrumConforms

HPLC>=97.5 %

Melting point212°C to 217°C

Specific optical rotation+150° to +156° (20°C, 589 nm) (C=1, dioxane)

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• Hydrocortisone is the synthetic formulation of the naturally occurring hormone, cortisol
• It is available as a white crystalline powder soluble in water, DMSO, and ethanol
• It is stable at room temperature but sensitive to light, and reactive in the presence of strong oxidizing agents

Applications

• Hydrocortisone works as an agonist to glucocorticoid receptors, thereby suppressing the inflammatory response of the immune system
• It’s administration induces gluconeogenesis, thus increasing endogenous blood sugar levels
• Research indicates a role for hydrocortisone in the metabolism of fat, protein, and carbohydrates

RUO – Research Use Only

Literature References

Ramamoorthy, S. and Cidlowski, J. A. Corticosteroids-Mechanisms of Action in Health and Disease. Rheum Dis Clin North Am. 2016, 42(1): 15–31.

Spireas, S.; Sadu, S.; and Grover, R. In vitro release evaluation of hydrocortisone liquisolid tablets. Journal of Pharmaceutical Sciences. 1998, 87(7), 867-872.

Oji, N. and Shreeve, W. W. Acute effects of hydrocortisone on gluconeogenesis from 14C- and 3H-labeled substrates in intact rats Endocrinology. 1967, 80(6), 1062-8.

Dandona. P; Thusu, K.; Hafeez, R.; Abdel-Rahman, E. Effect of hydrocortisone on oxygen free radical generation by mononuclear cells. Metabolism. 1998, 47(7), 788-791.