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Thermo Scientific Chemicals
Ceftriaxone sodium salt hemiheptahydrate
Ceftriaxone, CAS # 104376-79-6, sodium salt hemiheptahydrate is the sodium salt of ceftriaxone, a third-generation beta-lactam antibiotic of the cephalosporin class.
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| Catalog Number | Quantity |
|---|---|
| 455420010 | 1 g |
| 455420050 | 5 g |
| 455420250 | 25 g |
Price (EUR)
31,90
Each
Chemical Identifiers
CAS104376-79-6
IUPAC Nametetrasodium 3-({[(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}sulfanyl)-2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-1-ide (6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-{[(2-methyl-6-oxido-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate heptahydrate
Molecular FormulaC36H46N16Na4O21S6
InChI KeyRGDBKADCOSIOEV-MAODNAKNSA-J
SMILESO.O.O.O.O.O.O.[Na+].[Na+].[Na+].[Na+].CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(CSC3=NC(=O)C(=O)[N-]N3C)=C(N2C1=O)C([O-])=O)C1=CSC(N)=N1.CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(CSC3=NC(=O)C([O-])=NN3C)=C(N2C1=O)C([O-])=O)C1=CSC(N)=N1
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Specifications
Specification Sheet
Specification SheetWater=<10 %
Appearance (Color)White to light yellow
Infrared spectrumConforms
Appearance (Form)Crystalline powder
HPLC>=94 %
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Ceftriaxone is the sodium salt of ceftriaxone, a beta-lactam antibiotic of the cephalosporin class that works by inactivating penicillin-binding proteins
Applications
• Penicillin-binding protein inactivation inhibits peptidoglycan cross-linkage and leads to destruction of the cell wall and subsequent lysis
• It exhibits antibiotic activity against gram-negative bacteria
RUO – Research Use Only
Literature References
Grégoire, M.; Dailly, E.; Le Turnier, P.; Garot, D.; Guimard, T.; Bernard, L.; Tattevin, P.; Vandamme, Y.M.; Hoff, J.; Lemaitre, F.; Verdier, M.C.; Deslandes, G.; Bellouard, R.; Sébille, V.; Chiffoleau, A.; Boutoille, D.; Navas, D.; Asseray, N. High-Dose Ceftriaxone for Bacterial Meningitis and Optimization of Administration Scheme Based on Nomogram. Antimicrob Agents Chemother. 2019, 63(9), e00634-19.
Ross, J.D.C.; Brittain, C.; Cole, M.; Dewsnap, C.; Harding, J.; Hepburn, T.; Jackson, L.; Keogh, M.; Lawrence, T.; Montgomery, A.A.; Roberts, T.E.; Sprange, K.; Tan, W.; Thandi S, White J.; Wilson, J.; Duley, L. G-ToG trial team. Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG): a randomised non-inferiority trial. Lancet. 2019, 22, 393(10190), 2511-2520. Erratum in: Lancet. 2019, Erratum in: Lancet, 394(10205), 1230.