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2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one, 97%
2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one, 97%
2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one, 97%
Thermo Scientific Chemicals

2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one, 97%

CAS: 5381-99-7 | C7H4ClO3P | 202.53 g/mol
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5 g
25 g
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Catalog number B21086.14
also known as B21086-14
Price (EUR)
146,00
Each
Quantity:
25 g
Request bulk or custom format
Price (EUR)
146,00
Each
Chemical Identifiers
CAS5381-99-7
IUPAC Name2-chloro-2,4-dihydro-1,3,2-benzodioxaphosphinin-4-one
Molecular FormulaC7H4ClO3P
InChI KeyBVOITXUNGDUXRW-UHFFFAOYNA-N
SMILESClP1OC(=O)C2=CC=CC=C2O1
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SpecificationsSpecification SheetSpecification Sheet
FormCrystals or powder or crystalline powder or fused solid or clear liquid as melt
Assay (Titration ex Chloride)≥96.0 to ≤104.0%
Assay (GC)≥96.0%
Melting Point (clear melt)32.0-41.0?C
Appearance (Color)Colorless to white to pale yellow
2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one is a reagent used in phosphorylation and phosphitylation of alcohols and in the formation of H-phosphonates. It is also reactive cyclic phosphitylating reagent involved in fast coupling rates and hydrolytic cleavage more readily compare to that of a acyclic analog.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one is a reagent used in phosphorylation and phosphitylation of alcohols and in the formation of H-phosphonates. It is also reactive cyclic phosphitylating reagent involved in fast coupling rates and hydrolytic cleavage more readily compare to that of a acyclic analog.

Solubility
Soluble in acetonitrile, dichloromethane, tetrahydrofuron and dimethylformamide.

Notes
Light and heat sensitive. Incompatible with water and strong oxidizing agents.
RUO – Research Use Only

General References:

  1. Cai, X.; Janda, K. D. A chemoenzymatic approach toward the preparation of site-specific antibody-drug conjugates. Tetrahedron Lett. 2015, 56 (23), 3172-3175.
  2. Olea, C.; Joyce, G. F. Chapter Two-Ligand-Dependent Exponential Amplification of Self-Replicating RNA Enzymes. Methods Enzymol. 2015, 550, 23-39.