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cis-4-Hydroxy-L-proline, 99%
cis-4-Hydroxy-L-proline, 99%
cis-4-Hydroxy-L-proline, 99%
Thermo Scientific Chemicals

cis-4-Hydroxy-L-proline, 99%

CAS: 618-27-9 | C5H9NO3 | 131.13 g/mol
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Quantity:
250 mg
1 g
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Catalog number H27194.MD
also known as H27194-MD
Price (EUR)
222,00
Each
Quantity:
250 mg
Request bulk or custom format
Price (EUR)
222,00
Each
Chemical Identifiers
CAS618-27-9
SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White to cream or pale yellow
FormPowder
Assay (Aqueous acid-base Titration)≥98.5 to ≤101.5%
Identification (FTIR)Conforms
Optical Rotation-69.0° to -58° (c=2 in water)
cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line3 and rat pancreatic carcinoma cell line DSL6A. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
RUO – Research Use Only

General References:

  1. Heather Dickens et. al. Anticancer drug cis-4-hydroxy-L-proline: Correlation of preclinical toxicology with clinical parameters of liver function. Molecular Medicine Reports. 2008, 1(4), 459-464 .
  2. Roux A, Xu Y,; Heilier JF,; Olivier MF,; Ezan E,; Tabet JC,; Junot C. Annotation of the human adult urinary metabolome and metabolite identification using ultra high performance liquid chromatography coupled to a linear quadrupole ion trap-Orbitrap mass spectrometer. Analytical chemistry. 2012, 84 6429-6437.