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Fluconazole, 99%, Thermo Scientific Chemicals
Catalog number: J62015.03
1 g, Each
Thermo Scientific Chemicals
Fluconazole, 99%, Thermo Scientific Chemicals
Catalog number: J62015.03
1 g, Each
Quantity
Catalog number: J62015.03
also known as J62015-03
Price (EUR)
92,70 Online price
103,00
Each
Quantity
-
Chemical Identifiers
CAS
86386-73-4
IUPAC Name
2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
Molecular Formula
C13H12F2N6O
InChI Key
RFHAOTPXVQNOHP-UHFFFAOYSA-N
SMILES
OC(CN1C=NC=N1)(CN1C=NC=N1)C1=CC=C(F)C=C1F
Specifications
Specification SheetForm
Powder
Appearance (Color)
White to pale cream
Assay (special)
≥99.0%
Description
Fluconazole is used to treat a variety of fungal infections, especially Candida infections of the vagina (yeast infections), mouth, throat and bloodstream. It is also used by the people having weak immune system such as persons with neutropenia due to cancer chemotherapy, transplanted patients and premature infants.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species
• It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity
• It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)
• Mammalian cell demethylation is much less susceptible to fluconazole inhibition
Applications
• Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.
• Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene
• In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays
• It has also been used as a positive control in antifungal assay of plants
RUO – Research Use Only
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Safety and Handling
Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Acute oral toxicity
Category 4
Skin Corrosion/Irritation
Category 2
Serious Eye Damage/Eye Irritation
Category 2
Reproductive Toxicity
Category 1B
Specific target organ toxicity - (single exposure)
Category 2
Label Elements
Signal Word
Danger
Hazard Statements
H302 - Harmful if swallowed
H315 - Causes skin irritation
H319 - Causes serious eye irritation
H360D - May damage the unborn child
H371 - May cause damage to organs
Precautionary Statements
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P301 + P330 + P331 - IF SWALLOWED: rinse mouth. Do NOT induce vomiting
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
P312 - Call a POISON CENTER or doctor if you feel unwell
Additional EU labelling
Restricted to professional users