2-Hidroxipiridina, 98 %, Thermo Scientific Chemicals

Name: 2-Hidroxipiridina, 98 %, Thermo Scientific Chemicals
SKU: A14522.36
Price: 404.00 EUR

CAS: 142-08-5 | C5H5NO | 95.10 g/mol

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25 g

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500 g

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Número de catálogo A14522.36

también denominado A14522-36

Precio (EUR)

404,00

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Cantidad:

500 g

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Precio (EUR)

404,00

Each

Identificadores químicos

CAS142-08-5

Especificaciones Specification Sheet

Hoja de especificaciones

Identification (FTIR)Conforms

FormCrystalline powder or crystals

CommentMelting point is sensitive to water content

Melting Point (clear melt)102-111?C

Appearance (Color)White to cream to yellw to orange to pale brown

2-Hydroxypyridine is a bifunctional catalyst for a wide variety of acylation reactions, catalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols and in the aminolysis of a polyglutamate. It is used in peptide synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Aplicaciones
La 2-hidroxipiridina es un catalizador bifuncional para una amplia variedad de reacciones de acilación, catalizador para generar carbonatos de β-oxopropilo a partir de carbonatos cíclicos y alcoholes y en la aminólisis de un poliglutamato. Se utiliza en la síntesis de péptidos.

Solubilidad
Soluble en agua 450 g/L a 20 °C y etanol, ligeramente soluble en benceno y éter.

Notas
Almacenar en lugar fresco. Mantenga el recipiente bien cerrado en un lugar seco y bien ventilado. Almacenar lejos de los agentes oxidantes fuertes.

RUO – Research Use Only

General References:

Felix Plasser; Giovanni Granucci; Jiri Pittner; Mario Barbatti, Maurizio Persico; Hans Lischka. Surface hopping dynamics using a locally diabatic formalism: charge transfer in the ethylene dimer cation and excited state dynamics in the 2-pyridone dimer. Journal of Chemical Physics. 2012, 137 (22), 22A514.
Susan Blaser; Philipp Ottiger; Simon Lobsiger; Hans-Martin Frey; Samuel Leutwyler. Intermolecular clamping by hydrogen bonds: 2-pyridone⋅NH3. ChemPhysChem. 1999, 12 (10), 1841-1850.
Bifunctional catalyst for a wide variety of acylation reactions. See, for example: J. Chem. Soc. (C), 89 (1969).
For use of 2-pyridyl esters as active esters in peptide coupling, see: J. Chem. Soc.(C), 2896 (1971); Chem. Ber., 118, 468 (1985). The group can be introduced on to the N-protected peptide using DCC in pyridine, and is displaced by the amino-residue under mild conditions. For peptide reagents, see Appendix 6. Similar methodology has also been used in an improved preparation of trichloroethyl esters: Synthesis, 24 (1979).
Reacts with SOCl₂ to form di-2-pyridyl sulfite, a useful reagent for in situ formation of N-sulfinylamines, nitriles, isocyanides and carbodiimides under mild conditions: Tetrahedron Lett., 27, 1925 (1986).