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Higromicina B, Thermo Scientific Chemicals
Número de catálogo: J60681.MC
100 mg, Each
Thermo Scientific Chemicals
Higromicina B, Thermo Scientific Chemicals
Número de catálogo: J60681.MC
100 mg, Each
Cantidad
Número de catálogo: J60681.MC
también denominado J60681-MC
Precio (EUR)
49,86 Precio en línea
55,40
Each
Cantidad
-
Identificadores químicos
CAS
31282-04-9
IUPAC Name
(3'R,3aS,4S,4'R,5'R,6R,6'R,7S,7aS)-4-{[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy}-6'-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)-tetrahydro-3aH-spiro[[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol
Molecular Formula
C20H37N3O13
InChI Key
GRRNUXAQVGOGFE-KPBUCVLVSA-N
SMILES
CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3OC4(O[C@H]23)O[C@H]([C@@H](N)CO)[C@H](O)[C@@H](O)[C@H]4O)[C@@H]1O
Especificaciones
Hoja de especificacionesAppearance (Color)
Cream to plale brown
Form
Powder
Assay (HPLC)
≥ 90.0%
Water Content (Karl Fischer Titration)
15.0%
Potency
≥ 900 units/ mg
Descripción
An aminoglycoside antibiotic that kills bacteria by inhibiting protein synthesisHygromycin B is used for the selection and maintenance of prokaryotic and eukaryotic cells that contains the hygromycin resistance gene. This gene is frequently used as a selectable marker in research on plants. It stabilizes the transfer ribonucleic acid (tRNA)-ribosomal acceptor site, thereby inhibiting translocation. In addition to this, it serves as an aminoglycosidic antibiotic which inhibits protein synthesis.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Hygromycin is an aminoglycosidic compound that shows antibiotic activity. It is produced by Streptomyces hygroscopicus
- Hygromycin acts against both prokaryotic and eukaryotic cells, having the ability to inhibit protein synthesis. It also stabilizes the transfer ribonucleic acid (tRNA)-ribosomal acceptor site, thereby inhibiting translocation. This compound prevents ribosome translocation during translation elongation by binding the 30S rRNA proximal to the ribosomal E, P, and A sites
Application
- In clinical and plant research, this compound can be used as a marker to select and maintain prokaryotic and eukaryotic cells containing the hygromycin resistance gene
- Hygromycin also presents an anthelmintic activity against nematode parasites of chickens
RUO – Research Use Only
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Seguridad y manipulación
Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Acute oral toxicity
Category 2
Acute dermal toxicity
Category 1
Acute Inhalation Toxicity - Dusts and Mists
Category 2
Serious Eye Damage/Eye Irritation
Category 1
Respiratory Sensitization
Category 1
Skin Sensitization
Category 1
Label Elements
Signal Word
Danger
Hazard Statements
H300 + H310 + H330 - Fatal if swallowed, in contact with skin or if inhaled
H317 - May cause an allergic skin reaction
H318 - Causes serious eye damage
H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary Statements
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
P310 - Immediately call a POISON CENTER or doctor/physician
P330 - Rinse mouth