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alpha-D-Lactose monohydrate, 99.5+%
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alpha-D-Lactose monohydrate, 99.5+%
alpha-D-Lactose monohydrate, 99.5+%
alpha-D-Lactose monohydrate, 99.5+%
Thermo Scientific Chemicals

alpha-D-Lactose monohydrate, 99.5+%

alpha-D-Lactose monohydrate, synonym lactose, CAS # 5989-81-1, is the hydrate form of the disaccharide lactose. | CAS: 5989-81-1 | C12H24O12 | 360.312 g/mol
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Catalog number 125090050
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167,00
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Quantity:
5 kg
Packaging:
Plastic Drum
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Price (EUR)
167,00
Each
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Chemical Identifiers
CAS5989-81-1
IUPAC Name(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-{[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy}oxane-3,4,5-triol hydrate
Molecular FormulaC12H24O12
InChI KeyWSVLPVUVIUVCRA-KPKNDVKVSA-N
SMILESO.OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
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SpecificationsSpecification SheetSpecification Sheet
HPLC>=99.50 %
Water4.5 to 5.5 % (K.F.)
Specific optical rotationOn dry substance
Appearance (Form)Crystalline powder
Sulfated ash=<0.1 %
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Lactose is a disaccharide composed of glucose and galactose
  • Lactose is the major sugar found in dairy products such as milk and cheese
  • alpha-D-Lactose monohydrate is used as a carrier and stabilizer of products in the pharmaceutical and food industries

Applications

  • Lactose has been used in vitro to interact with carbohydrate recognition domains on a recombinant form of LGALS9, thus blocking downstream functions of the protein
  • It has been used as a control to study sugar dependency in Drosophila, which do not digest lactose
  • As a common component of pharmaceutical tablets, alpha-lactose has been used in laboratory settings to imitate drug administration
RUO – Research Use Only

General References:

  1. Walker, G.; Holland, C.R.; Ahmad, M.; Duncan, Q.M. Influence of process parameters on fluidised hot-melt granulation and tablet pressing of pharmaceutical powders. Chem. Eng. Sci.. 2005, 60 (14), 3867-3877.
  2. Montanuy, H.; Martínez-Barriocanal, A.; Casado, J.A. et al. (14 more authors) (2020)
  3. Gefitinib and afatinib show potential efficacy for Fanconi anemia-related head and neck
  4. cancer. Clinical Cancer Research, 26 (12). pp. 3044-3057. ISSN 1078-0432
  5. Wiersma, V.R.; de Bruyn, M.; Wei, Y.; van Ginkel, R.J.; Hirashima, M.; Niki, T.; Nishi, N.; Zhou, J.; Pouwels, S.D.; Samplonius, D.F.; Nijman, H.W.; Eggleton, P.; Helfrich, W.; Bremer, E. The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux. Autophagy. 2015, 11(8), 1373-88.
  6. Umezaki, Y.; Hayley, S.E.; Chu, M.L.; Seo, H.W.; Shah, P.; Hamada, F.N. Feeding-State-Dependent Modulation of Temperature Preference Requires Insulin Signaling in Drosophila Warm-Sensing Neurons. Curr Biol. 2018, 28(5), 779-787.e3.