2-Mercapto-1-methylimidazole, 98%, Thermo Scientific Chemicals

Name: 2-Mercapto-1-methylimidazole, 98%, Thermo Scientific Chemicals
SKU: 125500250
Price: 77.20 EUR

2-Mercapto-1-methylimidazole, CAS # 60-56-0, also known as methimazole, is a thyroid hormone antagonist used to study the treatment of thyroid disorders.

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Catalog number 125500250

Price (EUR)

77,20

Each

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Price (EUR)

77,20

Each

Chemical Identifiers

CAS60-56-0

IUPAC Name1-methyl-2,3-dihydro-1H-imidazole-2-thione

Molecular FormulaC4H6N2S

InChI KeyPMRYVIKBURPHAH-UHFFFAOYSA-N

SMILESCN1C=CNC1=S

Specifications

Specification Sheet

Appearance (Color)White to cream to yellow-brown

Titration with NaOH>=97.5 % (On dried substance)

Melting point140°C to 145°C

Loss on drying=<1 % (105°C, 2 hrs)

Infrared spectrumConforms

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• 2-Mercapto-1-methylimidazole, also known as methimazole, is an antithyroid medication

• Methimazole works by inhibiting the enzyme thyroid peroxidase (TPO), which is responsible for synthesizing the thyroid hormones triiodothyronine (T3) and thyroxine (T4) from the precursor thyroglobulin

Applications

• Methimazole has been used in laboratory settings to model olfactory epithelial degeneration

• May be used to study disruptions in iodide metabolism

• Methimazole has been used in Pharmacokinetics studies in the laboratory

RUO – Research Use Only

Literature references

Stanley, M.M.; Astwood, E.B. 1-Methyl-2-mercaptoimidazole; an antithyroid compound highly active in man. Endocrinology. 1949, 44(6), 588.

Ogawa, T.; Takezawa, K.; Shimizu, S.; Shimizu, T. Valproic acid promotes neural regeneration of olfactory epithelium in adult mice after methimazole-induced damage. Am J Rhinol Allergy. 2014, 28(2), e95-9.

Furman, B.L. in xPharm: The Comprehensive Pharmacology Reference. Methimazole. 2007 pp 1-4.