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Colistin sulfate salt
Colistin Sulfate salt (2:5), CAS # 1264-72-8, (synonym: Polymyxin E Complex), is a complex mixture of antibiotics, with Colistin A and B being the primary components. It has anti-bacterial activity against Gram-positive and Gram-negative bacteria and may also be used as a neuromuscular blocker.
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| Catalog Number | Quantity |
|---|---|
| 455390010 | 1 g |
| 455392500 | 250 mg |
Catalog number 455390010
Price (EUR)
168,65
Online exclusive
187,00Save 18,35 (10%)
Each
Quantity:
1 g
Price (EUR)
168,65
Online exclusive
187,00Save 18,35 (10%)
Each
Specifications
CAS1264-72-8
Chemical Name or MaterialColistin sulfate salt
Health Hazard 1Danger
Health Hazard 2GHS H Statement Toxic if swallowed.
Health Hazard 3GHS P Statement Wash face, hands and any exposed skin thoroughly after handling. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General description
• Colistin Sulfate salt is a stable, cationic, water-soluble, white powder composed of over 30 components
• Originally isolated from B. polymyxa, it inhibits the growth of the Gram-negative (e.g. E. coli, P. aeruginosa, P. fluorescens, and S. enterica), and Gram-positive bacteria (e.g. L. lactis, P. polymyxa, P. acidilactici, and S. aureus) by permeabilizing the bacterial cell membrane
Applications
• Colistin Sulfate has potent anti-endotoxin activity rendered through its ability to bind lippopolysaccharides that make up bacterial endotoxins
• This compound is often used in the management of multi-drug resistant Gram-negative infections
RUO – Research Use Only
Literature References:
Falagas, M. E.; Kasiakou, S. K.; Saravolatz, L. D. Colistin: The Revival of Polymyxins for the Management of Multidrug-Resistant Gram-Negative Bacterial Infections Clinical Infectious Diseases. 2005, 40 (9), 1333–1341.
Suzuki, T.; Inouye, H.; Fujikawa, K.; et al. Studies on the chemical structure of colistin. I. Fractionation, molecular weight determination, amino acid and fatty acid composition. J. Biochem. 1963, 54(1), 25-33.
Naghmouchi, K.; Hammami, R.; Fliss, I.; et al. Colistin A and colistin B among inhibitory substances of Paenibacillus polymyxa JB05-01-1. Arch. Microbiol. 2012, 194(5), 363-370.
Mitsugui, C.S.; Tognim, M.C.B.; Cardoso, C.L.; et al. In vitro activity of polymyxins in combination with β-lactams against clinical strains of Pseudomonas aeruginosa. Int. J. Antimicrob. 2011, 38(5), 447-450.