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Hypericin, 98%, Thermo Scientific Chemicals
Catalog number: H26425.MB
25 mg, Each
Thermo Scientific Chemicals
Hypericin, 98%, Thermo Scientific Chemicals
Catalog number: H26425.MB
25 mg, Each
Quantity
Catalog number: H26425.MB
also known as H26425-MB
Price (EUR)
430,00
Each
Quantity
-
Chemical Identifiers
CAS
548-04-9
IUPAC Name
7,11,13,16,18,22-hexahydroxy-5,24-dimethyloctacyclo[13.11.1.1²,¹⁰.0³,⁸.0⁴,²⁵.0¹⁹,²⁷.0²¹,²⁶.0¹⁴,²⁸]octacosa-1(27),2(28),3,5,7,10,12,14,16,18,21,23,25-tridecaene-9,20-dione
Molecular Formula
C30H16O8
InChI Key
BTXNYTINYBABQR-UHFFFAOYSA-N
SMILES
CC1=CC(O)=C2C(=O)C3=C(O)C=C(O)C4=C5C(O)=CC(O)=C6C(=O)C7=C(O)C=C(C)C8=C7C(=C56)C(C2=C18)=C34
Specifications
Specification SheetAssay from Supplier's CofA
≥97.5%
Appearance (Color)
Dark brown to black
Form
Powder
Description
Inhibitor of protein kinase C; induces photosynthesized apoptosisHypercin acts as an antibiotic and antiviral. It is involved in the inhibition of enzyme dopamine beta-hydroxylase action. It also exhibits an anti-HIV and anticancer drug. Further, it is useful in photodynamic therapy. In addition to this, it serves as an inhibitor of protein kinase C which induces photosynthesized apoptosis.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Hypericin is an anthraquinone derivative found in the yellow flower of Hypericum perforatum (also known as St. John's wort)
- This compound has the ability to inhibit protein kinase C, inducing photosynthesized apoptosis
Application
- It shows antibiotic and antiviral activities
- The antidepressant activity of this compound could be related to its ability to inhibit the neuronal uptake of serotonin, norepinephrine, dopamine, gamma-aminobutyric acid (GABA), and L-glutamate
- Since this compound is able to inhibit the assembly and shedding of virus particles in infected cells, hypericin may also prevent the replication of encapsulated viruses
- It has been described that this compound can also exhibit anti-HIV and anticancer activities
- Hypericin also displays an effective phototoxic activity and is able to trigger apoptotic pathways, resulting in the formation of reactive oxygen species
RUO – Research Use Only
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Safety and Handling
Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Acute oral toxicity
Category 4
Skin Sensitization
Category 1
Label Elements
Signal Word
Warning
Hazard Statements
H302 - Harmful if swallowed
H317 - May cause an allergic skin reaction
Precautionary Statements
P280 - Wear protective gloves/protective clothing
P301 + P330 + P331 - IF SWALLOWED: rinse mouth. Do NOT induce vomiting
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P312 - Call a POISON CENTER or doctor if you feel unwell
P333 + P313 - If skin irritation or rash occurs: Get medical advice/attention