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Phorbol 12-myristate 13-acetate, 95%, Thermo Scientific Chemicals
Catalog number: J63916.LB0
5 mg, Each
Thermo Scientific Chemicals
Phorbol 12-myristate 13-acetate, 95%, Thermo Scientific Chemicals
Catalog number: J63916.LB0
5 mg, Each
Quantity
Catalog number: J63916.LB0
also known as J63916-LB0
Price (EUR)
Price: 254,00
Online price: 228,60
Your price:
Quantity
-
Chemical Identifiers
CAS
16561-29-8
IUPAC Name
(1S,2S,6R,10S,11R,13S,14R,15R)-13-(acetyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0²,⁶.0¹¹,¹³]pentadeca-3,8-dien-14-yl tetradecanoate
Molecular Formula
C36H56O8
InChI Key
PHEDXBVPIONUQT-RGYGYFBISA-N
SMILES
CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(C)=O
Specifications
Specification SheetAppearance (Color)
White to pale cream
Assay from Suppliers CofA
≥94.0%
Form
Powder, film or foam, solid
Description
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
Solubility
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.
Notes
Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
Solubility
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.
Notes
Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
RUO – Research Use Only
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Safety and Handling
Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Acute oral toxicity
Category 2
Acute dermal toxicity
Category 1
Acute Inhalation Toxicity - Dusts and Mists
Category 1
Skin Corrosion/Irritation
Category 1
Serious Eye Damage/Eye Irritation
Category 1
Respiratory Sensitization
Category 1
Skin Sensitization
Category 1
Carcinogenicity
Category 2
Label Elements
Signal Word
Danger
Hazard Statements
H300 + H310 + H330 - Fatal if swallowed, in contact with skin or if inhaled
H314 - Causes severe skin burns and eye damage
H317 - May cause an allergic skin reaction
H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled
H351 - Suspected of causing cancer
Precautionary Statements
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P284 - Wear respiratory protection
P301 + P330 + P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting
P303 + P361 + P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower
P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
P310 - Immediately call a POISON CENTER or doctor/physician