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Chloroform, Molecular Biology Reagent
Catalog number: J67241.AP
500 mL, Each
Thermo Scientific Chemicals
Chloroform, Molecular Biology Reagent
Catalog number: J67241.AP
500 mL, Each
Quantity
Catalog number: J67241.AP
also known as J67241-AP
Price (EUR)
102,00
Each
Quantity
-
Chemical Identifiers
CAS
67-66-3
IUPAC Name
trichloromethane
Molecular Formula
CHCl3
InChI Key
HEDRZPFGACZZDS-UHFFFAOYSA-N
SMILES
ClC(Cl)Cl
Specifications
Specification SheetAssay from Suppliers CofA
≥99.5%
Assay (special)
Lead (Pb): ≤0.00001% (≤0.1 ppm)
Water Content (Karl Fischer Titration)
≤0.02%
Appearance (Color)
Clear colorless
Form
Liquid
Description
Chloroform is a common laboratory reagent favored for use as a solvent due to the compounds relative unreactivity and miscibility with most organic compounds. Chloroform is also used in organic synthesis as a source for CCl2. In the swine tracheal smooth muscle, chloroform has been demonstrated to directly and in a concentration dependent manner induce contractions. It has been observed that Chloroform can release Ca2+ from ryanodine sensitive receptors in chloroform-induced contraction in swine tracheal smooth muscle. At concentrations of 100 and 250 ppm in mouse splenocyte, basal proliferation was increased yet a decrease in circulating neutrophils was documented.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Chloroform is a common laboratory reagent favored for use as a solvent due to the compounds relative unreactivity and miscibility with most organic compounds. Chloroform is also used in organic synthesis as a source for CCl2. In the swine tracheal smooth muscle, chloroform has been demonstrated to directly and in a concentration dependent manner induce contractions. It has been observed that Chloroform can release Ca2+ from ryanodine sensitive receptors in chloroform-induced contraction in swine tracheal smooth muscle. At concentrations of 100 and 250 ppm in mouse splenocyte, basal proliferation was increased yet a decrease in circulating neutrophils was documented.
Solubility
Soluble in water at 20°C 8 g/L.
Notes
Stabilized with approx. 50 ppm amylene
Chloroform is a common laboratory reagent favored for use as a solvent due to the compounds relative unreactivity and miscibility with most organic compounds. Chloroform is also used in organic synthesis as a source for CCl2. In the swine tracheal smooth muscle, chloroform has been demonstrated to directly and in a concentration dependent manner induce contractions. It has been observed that Chloroform can release Ca2+ from ryanodine sensitive receptors in chloroform-induced contraction in swine tracheal smooth muscle. At concentrations of 100 and 250 ppm in mouse splenocyte, basal proliferation was increased yet a decrease in circulating neutrophils was documented.
Solubility
Soluble in water at 20°C 8 g/L.
Notes
Stabilized with approx. 50 ppm amylene
RUO – Research Use Only
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Safety and Handling
Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Acute oral toxicity
Category 4
Acute Inhalation Toxicity - Vapors
Category 3
Skin Corrosion/Irritation
Category 2
Serious Eye Damage/Eye Irritation
Category 2
Carcinogenicity
Category 2
Reproductive Toxicity
Category 2
Specific target organ toxicity - (single exposure)
Category 3
Specific target organ toxicity - (repeated exposure)
Category 1
Label Elements
Signal Word
Danger
Hazard Statements
H302 - Harmful if swallowed
H315 - Causes skin irritation
H319 - Causes serious eye irritation
H331 - Toxic if inhaled
H336 - May cause drowsiness or dizziness
H351 - Suspected of causing cancer
H361d - Suspected of damaging the unborn child
H372 - Causes damage to organs through prolonged or repeated exposure
Precautionary Statements
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
P311 - Call a POISON CENTER or doctor/physician
Additional EU labelling
For use in industrial installations only