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4-Nitrophthalic anhydride, tech. 90%
4-Nitrophthalic anhydride, tech. 90%
4-Nitrophthalic anhydride, tech. 90%
Thermo Scientific Chemicals

4-Nitrophthalic anhydride, tech. 90%

CAS: 5466-84-2 | C8H3NO5 | 193.114 g/mol
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25 g
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Catalog number L08020.06
also known as L08020-06
Price (EUR)
59,10
Each
Quantity:
5 g
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Price (EUR)
59,10
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Chemical Identifiers
CAS5466-84-2
IUPAC Name5-nitro-1,3-dihydro-2-benzofuran-1,3-dione
Molecular FormulaC8H3NO5
InChI KeyMMVIDXVHQANYAE-UHFFFAOYSA-N
SMILES[O-][N+](=O)C1=CC=C2C(=O)OC(=O)C2=C1
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SpecificationsSpecification SheetSpecification Sheet
Assay (GC)≥88.0%
Appearance (Color)Pale yellow to cream
FormCrystals or powder or crystalline powder
4-Nitrophthalic anhydride is used an an intermediate for the synthesis of a benzimidazole PARP inhibitor I (succinate salt) (ABT-472).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4-Nitrophthalic anhydride is used an an intermediate for the synthesis of a benzimidazole PARP inhibitor I (succinate salt) (ABT-472).

Solubility
Hydrolyzes in water.

Notes
Moisture Sensitive. Store away from strong bases and oxidizing agents. Incompatible with water, bases, strong acids and oxidizing agents.
RUO – Research Use Only

General References:

  1. R. L. Markezich; O. S. Zamek; P. E. Donahue; F. J. Williams. Reactions of 4-nitrophthalic anhydride with potassium fluoride and potassium nitrite.J. Org. Chem.1977, 42 (21), 3435-3436.
  2. Ellis K. Fields; Seymour Meyerson. Reactions of 4-nitrophthalic anhydride.Tetrahedron Letters.1971, 12 719-722.
  3. Reagent for the protection of primary amines as the corresponding phthalimides. Cleavage can be carried out with methylhydrazine: Synlett, 63 (1994).