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Citations & References (1)
Fluorescein-ERM (LRRKtide)
A fluorescein-labeled peptide substrate based upon ezrin/radixin/moesin (ERM) that is phosphorylated by LRRK2 and LRRK2 mutants.For use in combination withRead more
| Catalog Number | Quantity |
|---|---|
| PV4901 | 1 mg |
Catalog number PV4901
Price (EUR)
960,00
Each
Quantity:
1 mg
Price (EUR)
960,00
Each
A fluorescein-labeled peptide substrate based upon ezrin/radixin/moesin (ERM) that is phosphorylated by LRRK2 and LRRK2 mutants.
For use in combination with the LanthaScreen™ Tb-anti-ERM (pLRRKtide) Antibody (PV4899) to evalute inhibitors in medium to high throughput screening applications.
For use in combination with the LanthaScreen™ Tb-anti-ERM (pLRRKtide) Antibody (PV4899) to evalute inhibitors in medium to high throughput screening applications.
For Research Use Only. Not for use in diagnostic procedures.
Specifications
Amino Acid SequenceFluorescein-GAGRLGRDKYKTLRQIRQ
Assay EntryBiochemical terbium phospho-specific activity
Gene ID (Entrez)120892
Label or DyeFITC (Fluorescein)
Molecular Weight (g/mol)2475.8 Da
Quantity1 mg
Shipping ConditionDry Ice
SubstrateERM (LRRKtide)
Target EntryLRRK2 D1994A, LRRK2 R1441C, LRRK2 I2020T, LRRK2 G2019S, LRRK2
Validated KinasesLRRK2
Detection MethodFluorescence
Substrate PropertiesPeptide-Based Substrate
Substrate TypeKinase Substrate
Target EnzymeSerine/Threonine Kinases
Unit SizeEach
Contents & Storage
400 μM Fluorescein-ERM (LRRKtide) peptide substrate in water. Store at -20°C and protect from light.
Citations & References (1)
Citations & References
Abstract
Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.
Journal:FEBS J
PubMed ID:19076219
Mutations in leucine-rich repeat kinase 2 (LRRK2) comprise the leading cause of autosomal dominant Parkinson's disease, with age of onset and symptoms identical to those of idiopathic forms of the disorder. Several of these pathogenic mutations are thought to affect its kinase activity, so understanding the roles of LRRK2, and