ERM (LRRKtide) Substrate
Product Image
Citations & References (1)

ERM (LRRKtide) Substrate

A peptide substrate based upon ezrin/radixin/moesin (ERM) that is phosphorylated by LRRK2 and LRRK2 mutants. For use with the Adapta™Read more
Have Questions?
Catalog NumberQuantity
PV50931 mL
Catalog number PV5093
Price (EUR)
912,00
Each
Add to cart
Quantity:
1 mL
Price (EUR)
912,00
Each
Add to cart
A peptide substrate based upon ezrin/radixin/moesin (ERM) that is phosphorylated by LRRK2 and LRRK2 mutants. For use with the Adapta™ Universal Kinase Assay (PV5099).
For Research Use Only. Not for use in diagnostic procedures.
Specifications
Amino Acid SequenceRLGRDKYKTLRQIRQ
Assay EntryBiochemical ADP accumulation
Gene ID (Entrez)120892
Molecular Weight (g/mol)1931.2 Da
Quantity1 mL
Shipping ConditionDry Ice
Substratepeptide based upon ezrin/radixin/moesin (ERM)
Target EntryLRRK2 G2019S, LRRK2
Validated KinasesLRRK2
Detection MethodFluorescence
Substrate PropertiesPeptide-Based Substrate
Substrate TypeKinase Substrate
Target EnzymeSerine/Threonine Kinases
Unit SizeEach
Contents & Storage
2 mM ERM (LRRKtide) peptide substrate in 50 mM HEPES (pH 7.5), 0.01% Brij-35, 10 mM MgCl2 and 1 mM EGTA. Store at -20°C.

Citations & References (1)

Citations & References
Abstract
Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.
Authors:Anand VS, Reichling LJ, Lipinski K, Stochaj W, Duan W, Kelleher K, Pungaliya P, Brown EL, Reinhart PH, Somberg R, Hirst WD, Riddle SM, Steven P B,
Journal:FEBS J
PubMed ID:19076219
Mutations in leucine-rich repeat kinase 2 (LRRK2) comprise the leading cause of autosomal dominant Parkinson's disease, with age of onset and symptoms identical to those of idiopathic forms of the disorder. Several of these pathogenic mutations are thought to affect its kinase activity, so understanding the roles of LRRK2, and ... More