Orbitrap™ Astral™ Zoom Mass Spectrometers

Accelerate discoveries forward with increased flexibility, faster throughput, deeper coverage, higher sensitivty, and accurate and precise quantitation with the Thermo Scientific Orbitrap Astral Zoom mass spectrometer. Designed to achieve the next generation of breakthroughs in proteomics, metabolomics, lipidomics, and biopharma research with faster scan rates, improved duty cycle, sub-cellular sensitivity, and novel acquisition methods. Turn ideas into insights, advancing science exponentially and driving clinical research forward to interventions that improve outcomes.

Upgraded instrument architecture leveraging the power of parallelized high-resolution accurate mass acquisition with the Orbitrap and Astral analyzers to enable:

Faster throughput

• Identify over 8,000 proteins from 300 samples per day

Deeper coverage

• Identify over 200,000 unique peptides from a single-shot experiment in under 1 hour
• Comprehensively characterize small molecule samples with fragmentation of over 90% of compounds in a single injection with data-dependent acquisition

Higher sensitivity

• Identify over 5,500 proteins from a single cell at a throughput of 50 samples per day

Accurate and Precise Quantitation

• Achieve a linear dynamic range of 6 orders of magnitude for metabolites using simultaneous quantitation and discovery (SQUAD) workflows
• Increase multiplexing with TMT HR mode to support TMTpro 35plex label reagents experiments

Increased Flexibility

• Perform rapid intact, top-down, and middle-down measurements with the Biopharma option, enabling improved pressure regulation, an extended Orbitrap analyzer scan range up to m/z 8,000, and top-down and middle-down MS2 measurements with the Astral analyzer
• Leverage faster stepped collision energy to increase spectral quality at speed for applications including N-linked glycoproteomics and metabolomics