Methotrexate, Fluorescein, triammonium Salt (Fluorescein Methotrexate)
Methotrexate, Fluorescein, triammonium Salt (Fluorescein Methotrexate)
引用資料與參考文獻 (57)
Invitrogen™

Methotrexate, Fluorescein, triammonium Salt (Fluorescein Methotrexate)

The green-fluorescent fluorescein methotrexate (absorption⁄emission maxima ∼496⁄516 nm) can be used to probe dihydrofolate reductase (DHFR) expression by fluorescence microscopy深入閱讀
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產品號碼Quantity
M1198MP1 mg
產品號碼 M1198MP
價格 (HKD)
3,810.00
Each
新增至購物車
Quantity:
1 mg
價格 (HKD)
3,810.00
Each
新增至購物車
The green-fluorescent fluorescein methotrexate (absorption⁄emission maxima ∼496⁄516 nm) can be used to probe dihydrofolate reductase (DHFR) expression by fluorescence microscopy or flow cytometry.
For Research Use Only. Not for use in diagnostic procedures.
規格
Label TypeClassic Dyes
Molecular FormulaC46H54N14O9S
Quantity1 mg
Recommended StorageStore in freezer (-5°C to -30°C) and protect from light.
Shipping ConditionRoom Temperature
Physical FormSolid
Product TypeFluorescein Methotrexate
Unit SizeEach

引用資料與參考文獻 (57)

引用資料與參考文獻
Abstract
Xenobiotic transport across isolated brain microvessels studied by confocal microscopy.
Authors:Miller DS,Nobmann SN,Gutmann H,Toeroek M,Drewe J,Fricker G
Journal:Molecular pharmacology
PubMed ID:11093774
Visualization of membrane-associated folate transport proteins.
Authors:Pope LE, Fan J, Chang CM, Minskoff SA, Vitols KS, Huennekens FM
Journal:Adv Enzyme Regul
PubMed ID:2516406
'Transport of Methotrexate (MTX) into cells, via the "reduced folate" transport system, is a critical factor in the effectiveness of the drug in cancer chemotherapy, and defective transport is one of the principal types of resistance to MTX. Probes capable of detecting membrane-associated folate transport proteins (ftp''s) in individual cells ... More
MRP2 and acquired tolerance to inorganic arsenic in the kidney of killifish (Fundulus heteroclitus).
Authors:Miller DS, Shaw JR, Stanton CR, Barnaby R, Karlson KH, Hamilton JW, Stanton BA,
Journal:Toxicol Sci
PubMed ID:17324950
'We used proximal tubules isolated from the killifish, Fundulus heteroclitus, to examine the effect of environmentally relevant, sublethal levels of arsenic on the function and expression of MRP2, an ABC transporter that transports xenobiotics into urine, including arsenic-glutathione conjugates. Exposure of fish to arsenic as sodium arsenite (4-14 days) increased ... More
Characterization of a lipophilic antifolate resistance provoked by treatment of mammalian cells with the antiparasitic agent pyrimethamine.
Authors:Assaraf YG, Slotky JI
Journal:J Biol Chem
PubMed ID:8440739
'We describe the characterization of an antitumor drug resistance following multiple step selection of hamster cells to the 2,4-diaminopyrimidines (DAP) metoprine, pyrimethamine (Pyr), and trimethoprim (Tmp). Pyr and Tmp are DAP lipophilic antifolates currently used as antiparasitic and antibacterial antibiotics, respectively. Dihydrofolate reductase (DHFR) from hamster cells bore a low ... More
Defective transport as a mechanism of acquired resistance to methotrexate in patients with acute lymphocytic leukemia.
Authors:Trippett T, Schlemmer S, Elisseyeff Y, Goker E, Wachter M, Steinherz P, Tan C, Berman E, Wright JE, Rosowsky A
Journal:Blood
PubMed ID:1381235
'Although the mechanisms of resistance to methotrexate (MTX) are known in experimental tumors made resistant to this drug, little information is available regarding acquired resistance to MTX in patients. A competitive displacement assay using the fluorescent lysine analogue of MTX, N-(4-amino-4-deoxy-N10-methylpteroyl)-N epsilon-(4''-fluorescein-thiocarbamyl)-L-lysine (PT430), was developed as a sensitive method of ... More
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