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Fisher Scientific™
GSK2578215A, Tocris Bioscience™
Potent, selective LRRK2 inhibitor; brain penetrant
Catalog number 462910
also known as FISHERMIS-462910-EACH
Price (KRW)
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Potent, selective LRRK2 inhibitor; brain penetrant
Potent LRRK2 inhibitor (IC50 values are 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Displays selectivity for LRRK2 over a panel of 460 other kinases. Blocks Ser910 and Ser935 phosphorylation in vitro and in peripheral tissues in vivo. Brain penetrant.
Specifications
CAS1285515-21-0
Chemical Name or MaterialGSK2578215A
Formula Weight399.42
IUPAC Name5-(2-fluoropyridin-4-yl)-2-phenylmethoxy-N-pyridin-3-ylbenzamide
InChI KeyWCIGMFCFPXZRMQ-UHFFFAOYSA-N
Molecular FormulaC24H18FN3O2
PubChem CID68107965
Recommended StorageStore at Room Temperature
SMILESC1=CC=C(C=C1)COC2=C(C=C(C=C2)C3=CC(=NC=C3)F)C(=O)NC4=CN=CC=C4
Synonymunii-q641jsf42x, 2-benzyloxy-5-2-fluoropyridin-4-yl-n-pyridin-3-yl benzamide, lrrk2-kinase inhibitor, benzamide, 5-2-fluoro-4-pyridinyl-2-phenylmethoxy-n-3-pyridinyl, 5-2-fluoro-4-pyridinyl-2-phenylmethoxy-n-3-pyridinylbenzamide, 5-2-fluoropyridin-4-yl-2-phenylmethoxy-n-pyridin-3-ylbenzamide, 5-2-fluoro-4-pyridinyl-2-phenylmethyl oxy-n-3-pyridinylbenzamide
Molecular Weight (g/mol)399.425
Percent Purity>99%
Quantity10 mg
Unit SizeEach