Thermo Fisher Scientific provides a complete collection of validated positive and negative controls for the TrueGuide Synthetic gRNA product line to help maximize your editing performance. This positive control against HPRT1 targets an intronic region and has achieved editing efficiencies of up to 65% in a variety of human cell lines. Use the HPRT1 control to easily determine the optimal conditions for delivering CRISPR/Cas9 tools to your cell type, allowing you to move forward in your editing experiments with confidence and minimize downstream effort to isolate and validate your edited clones.