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인용 및 참조 문헌 (5)
Thermo Scientific™
DMS (dimethyl suberimidate)
Thermo Scientific Pierce DMS is dimethyl suberimidate, a membrane-permeable crosslinker that contains an amine-reactive imidoester group at each end of자세히 알아보기
| 카탈로그 번호 | 수량 |
|---|---|
| 20700 | 1 g |
카탈로그 번호 20700
제품 가격(KRW)
228,000
Online offer
Ends: 31-Dec-2025
268,000할인액 40,000 (15%)
Each
수량:
1 g
제품 가격(KRW)
228,000
Online offer
Ends: 31-Dec-2025
268,000할인액 40,000 (15%)
Each
Thermo Scientific Pierce DMS is dimethyl suberimidate, a membrane-permeable crosslinker that contains an amine-reactive imidoester group at each end of an 8-atom spacer arm.
Features of dimethyl suberimidate:
• Reactive groups: imidoester (both ends)
• Reactive towards: amino groups (primary amines)
• Longest of three similar imidoester crosslinkers, which include DMA, DMP and DMS
• Water-soluble
• Imidoesters react with amines at alkaline pH values (pH 8-10) to form amidine bond
• Amidine bond retains net charge character of protein primary amine to which it reacts
• Reversible at high pH values
• Tool for study of quarternary structure of proteins
Product References
Crosslinker Application Guide -- search for recent literature references for this product
Related Products
DMA (dimethyl adipimidate)
DMP (dimethyl pimelimidate)
DTBP (Wang and Richard's Reagent)
Features of dimethyl suberimidate:
• Reactive groups: imidoester (both ends)
• Reactive towards: amino groups (primary amines)
• Longest of three similar imidoester crosslinkers, which include DMA, DMP and DMS
• Water-soluble
• Imidoesters react with amines at alkaline pH values (pH 8-10) to form amidine bond
• Amidine bond retains net charge character of protein primary amine to which it reacts
• Reversible at high pH values
• Tool for study of quarternary structure of proteins
Product References
Crosslinker Application Guide -- search for recent literature references for this product
Related Products
DMA (dimethyl adipimidate)
DMP (dimethyl pimelimidate)
DTBP (Wang and Richard's Reagent)
For Research Use Only. Not for use in diagnostic procedures.
사양
세포 투과성Yes
설명DMS
형태Powder
라벨링 방법Chemical Labeling
분자량273.2
페길레이티드No
제품라인Pierce
수량1 g
반응성 부분Imidoester
배송 조건Ambient
용해도Water
스페이서 암 길이11.0 Å
수용성Yes
화학물질 반응성Amine-Amine
CleavableNo
교차결합제 유형Homobifunctional
형식Standard
제품 유형Crosslinker
스페이서Medium (10 to 30 Å)
Unit SizeEach
구성 및 보관
Upon receipt store desiccated at 4°C.
자주 묻는 질문(FAQ)
Can you provide the shelf-life for DMS (dimethyl suberimidate)?
인용 및 참조 문헌 (5)
인용 및 참조 문헌
Abstract
Discovery of lung cancer biomarkers by profiling the plasma proteome with monoclonal antibody libraries.
Journal:Mol Cell Proteomics
PubMed ID:21947365
'A challenge in the treatment of lung cancer is the lack of early diagnostics. Here, we describe the application of monoclonal antibody proteomics for discovery of a panel of biomarkers for early detection (stage I) of non-small cell lung cancer (NSCLC). We produced large monoclonal antibody libraries directed against the
The structural characterization of a prophage-encoded extracellular DNase from Streptococcus pyogenes.
Journal:Nucleic Acids Res
PubMed ID:21948797
'The pathogenic bacterium Group A Streptococcus pyogenes produces several extracellular DNases that have been shown to facilitate invasive infection by evading the human host immune system. DNases degrade the chromatin in neutrophil extracellular traps, enabling the bacterium to evade neutrophil capture. Spd1 is a type I, nonspecific ßßa/metal-dependent nuclease from
Outer membrane lipoprotein Lpp is Gram-negative bacterial cell surface receptor for cationic antimicrobial peptides.
Journal:J Biol Chem
PubMed ID:22084237
Antimicrobial peptides/proteins (AMPs) are important components of the host innate defense mechanisms. Here we demonstrate that the outer membrane lipoprotein, Lpp, of Enterobacteriaceae interacts with and promotes susceptibility to the bactericidal activities of AMPs. The oligomeric Lpp was specifically recognized by several cationic a-helical AMPs, including SMAP-29, CAP-18, and LL-37;
Inhibition of RNase L and RNA-dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunity.
Journal:J Biol Chem
PubMed ID:21636578
RNase L and RNA-dependent protein kinase (PKR) are effectors of the interferon antiviral response that share homology in their pseudokinase and protein kinase domains, respectively. Sunitinib is an orally available, ATP-competitive inhibitor of VEGF and PDGF receptors used clinically to suppress angiogenesis and tumor growth. Sunitinib also impacts IRE1, an
Human mitochondrial DNA helicase TWINKLE is both an unwinding and annealing helicase.
Journal:J Biol Chem
PubMed ID:22383523
TWINKLE is a nucleus-encoded human mitochondrial (mt)DNA helicase. Point mutations in TWINKLE are associated with heritable neuromuscular diseases characterized by deletions in the mtDNA. To understand the biochemical basis of these diseases, it is important to define the roles of TWINKLE in mtDNA metabolism by studying its enzymatic activities. To