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인용 및 참조 문헌 (2)
Thermo Scientific™
SIA (succinimidyl iodoacetate)
Thermo Scientific Pierce SIA is a very short (1.5 angstrom) crosslinker for amine-to-sulfhydryl conjugation via N-hydroxysuccinimide (NHS) ester and iodoacetyl자세히 알아보기
| 카탈로그 번호 | 수량 |
|---|---|
| 22349 | 50 mg |
카탈로그 번호 22349
제품 가격(KRW)
159,000
Online offer
Ends: 31-Dec-2025
186,000할인액 27,000 (15%)
Each
수량:
50 mg
제품 가격(KRW)
159,000
Online offer
Ends: 31-Dec-2025
186,000할인액 27,000 (15%)
Each
Thermo Scientific Pierce SIA is a very short (1.5 angstrom) crosslinker for amine-to-sulfhydryl conjugation via N-hydroxysuccinimide (NHS) ester and iodoacetyl reactive groups.
Features of SIA:
• Reactive groups: NHS ester and iodoacetyl
• Reactive toward: amino and sulfhydryl groups
• Shortest sulfhydryl-reactive and amine-reactive heterobifunctional crosslinker available; compare to SIAB
• NHS ester reacts with primary amines at pH 7-9 to form a stable amide bond
• Iodoacetyl group reacts with sulfhydryl groups at pH > 7.5 to form stable thioether bond
• Non-cleavable
• Water-insoluble (dissolve first in DMF or DMSO)
Product References:
Crosslinker Application Guide -- search for recent literature references for this product
Features of SIA:
• Reactive groups: NHS ester and iodoacetyl
• Reactive toward: amino and sulfhydryl groups
• Shortest sulfhydryl-reactive and amine-reactive heterobifunctional crosslinker available; compare to SIAB
• NHS ester reacts with primary amines at pH 7-9 to form a stable amide bond
• Iodoacetyl group reacts with sulfhydryl groups at pH > 7.5 to form stable thioether bond
• Non-cleavable
• Water-insoluble (dissolve first in DMF or DMSO)
Product References:
Crosslinker Application Guide -- search for recent literature references for this product
For Research Use Only. Not for use in diagnostic procedures.
사양
세포 투과성Yes
설명SIA
형태Solid
라벨링 방법Chemical Labeling
분자량283.02
페길레이티드No
제품라인Pierce
수량50 mg
반응성 부분Haloacetyl, NHS Ester
배송 조건Ambient
용해도DMF, DMSO
스페이서 암 길이1.5 Å
수용성No
화학물질 반응성Amine-Sulfhydryl
CleavableNo
교차결합제 유형Heterobifunctional
형식Standard
제품 유형Crosslinker
스페이서Short (<10 Å)
Unit SizeEach
구성 및 보관
Upon receipt store at 4°C protected from moisture.
자주 묻는 질문(FAQ)
Can you provide the shelf-life for SIA (succinimidyl iodoacetate)?
인용 및 참조 문헌 (2)
인용 및 참조 문헌
Abstract
A central role for the T1 domain in voltage-gated potassium channel formation and function.
Journal:J Biol Chem
PubMed ID:11312262
To interpret the recent atomic structures of the Kv (voltage-dependent potassium) channel T1 domain in a functional context, we must understand both how the T1 domain is integrated into the full-length functional channel protein and what functional roles the T1 domain governs. The T1 domain clearly plays a role in
Formation of protein tyrosine ortho-semiquinone radical and nitrotyrosine from cytochrome c-derived tyrosyl radical.
Journal:J Biol Chem
PubMed ID:14761966
Oxidative alteration of mitochondrial cytochrome c (cyt c) has been linked to disease pathophysiology and is one of the causative factors for pro-apoptotic events. Hydrogen peroxide induces a short-lived cyt c-derived tyrosyl radical as detected by the electron spin resonance (ESR) spin-trapping technique. This investigation was undertaken to characterize the