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인용 및 참조 문헌 (4)
Thermo Scientific™
PMPI (p-maleimidophenyl isocyanate)
Thermo Scientific Pierce PMPI is a maleimide-and-isocyanate crosslinker for attaching compounds to sulfhydryl groups (cysteines) after conjugating the linker to자세히 알아보기
| 카탈로그 번호 | 수량 |
|---|---|
| 28100 | 50 mg |
카탈로그 번호 28100
제품 가격(KRW)
301,000
Online offer
Ends: 31-Dec-2025
354,000할인액 53,000 (15%)
Each
수량:
50 mg
제품 가격(KRW)
301,000
Online offer
Ends: 31-Dec-2025
354,000할인액 53,000 (15%)
Each
Thermo Scientific Pierce PMPI is a maleimide-and-isocyanate crosslinker for attaching compounds to sulfhydryl groups (cysteines) after conjugating the linker to hydroxyl groups on a molecule by urethane (carbamate) bonds.
Features of PMPI:
• Reactive groups: maleimide and isocyanate
• Reactive towards: sulfhydryl and hydroxyl groups
• Short (8.7A), sulfhydryl-to-hydroxyl crosslinker with an aromatic spacer arm (noncleavable)
• Maleimide group reacts with sulfhydryl groups to form stable thioether linkages
• Isocyanate reacts with non-aqueous hydroxyl groups to form carbamate linkage
• Excellent tool for conjugating hydroxyl-containing compounds such as steroids and vitamins
• Targets and reaction solutions must not contain primary amines
Features of PMPI:
• Reactive groups: maleimide and isocyanate
• Reactive towards: sulfhydryl and hydroxyl groups
• Short (8.7A), sulfhydryl-to-hydroxyl crosslinker with an aromatic spacer arm (noncleavable)
• Maleimide group reacts with sulfhydryl groups to form stable thioether linkages
• Isocyanate reacts with non-aqueous hydroxyl groups to form carbamate linkage
• Excellent tool for conjugating hydroxyl-containing compounds such as steroids and vitamins
• Targets and reaction solutions must not contain primary amines
For Research Use Only. Not for use in diagnostic procedures.
사양
세포 투과성Not determined
설명PMPI
형태Solid
라벨링 방법Chemical Labeling
분자량307.1
페길레이티드No
제품라인Pierce
수량50 mg
반응성 부분Maleimide, Isocyanate
배송 조건Ambient
용해도DMF, DMSO
스페이서 암 길이8.7 Å
수용성No
화학물질 반응성Carboxyl-Sulfhydryl
CleavableNo
교차결합제 유형Heterobifunctional
형식Standard
제품 유형Crosslinker
스페이서Short (<10 Å)
Unit SizeEach
구성 및 보관
Upon receipt store at 4°C protected from moisture.
인용 및 참조 문헌 (4)
인용 및 참조 문헌
Abstract
X-ray photoelectron spectroscopy and infrared spectroscopy study of maleimide-activated supports for immobilization of oligodeoxyribonucleotides.
Journal:Nucleic Acids Res
PubMed ID:15537837
'Surface-tethered nucleic acids are widely applied in solid-phase assays in which complementary strands must be detected against a complex mixture of other sequences. In response to such needs, numerous methods have been developed for immobilizing nucleic acids on solid supports. Often, detailed analysis of associated chemical transformations and of potential
Direct electrical detection of DNA synthesis.
Journal:Proc Natl Acad Sci U S A
PubMed ID:16614066
'Rapid, sequence-specific DNA detection is essential for applications in medical diagnostics and genetic screening. Electrical biosensors that use immobilized nucleic acids are especially promising in these applications because of their potential for miniaturization and automation. Current DNA detection methods based on sequencing by synthesis rely on optical readouts; however, a
Discovering ligands for a microRNA precursor with peptoid microarrays.
Journal:Nucleic Acids Res
PubMed ID:19561197
We have screened peptoid microarrays to identify specific ligands for the RNA hairpin precursor of miR-21, a microRNA involved in cancer and heart disease. Microarrays were printed by spotting a library of 7680 N-substituted oligoglycines (peptoids) onto glass slides. Two compounds on the array specifically bind RNA having the sequence
Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter.
Journal:J Biol Chem
PubMed ID:18644784
Human ABCG2 is a plasma membrane glycoprotein working as a homodimer or homo-oligomer. The protein plays an important role in the protection/detoxification of various tissues and may also be responsible for the multidrug-resistant phenotype of cancer cells. In our previous study we found that the 5D3 monoclonal antibody shows a