The Tango™ CXCR7-bla U2OS cells contain the human Chemokine (C-X-C motif) receptor 7 (CXCR7) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line. This parental cell line stably expresses a beta-arrestin/TEV protease fusion protein and the beta-lactamase (bla) reporter gene under the control of a UAS response element. The Tango™ CXCR7-bla U2OS cells are functionally validated for Z' and EC50 concentrations of SDF1a. In addition, Tango™ CXCR7-bla U2OS cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary. For Academic pricing please login or contact us at discoverysciences@invitrogen.com.
For Research Use Only. Not for use in diagnostic procedures.
사양
등록 번호
NM_020311.2
어세이 입력
Cell-based beta-arrestin recruitment
셀 상태
Dividing Cells
세포질 후미
Native Tail
검출 방법
Fluorescent
용도(애플리케이션)
FRET
유전자 기호
CXCR7
인간 단백질 분류
G-Protein Coupled Receptor (GPCR)
개체군 상태
Single Cell Clone Origin
제품라인
GeneBLAzer™, Tango™
판독
End Point
타겟 입력
CXCR7
유형
U2OS Cell
세포주
U2OS
System Type
Tango™
Druggable Target
GPCR
구성 및 보관
Contents: K1832 Tango™ CXCR7-bla U2OS cells (LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol). Includes: • Tango™ CXCR7-bla U2OS cells • Tango™ CXCR7-bla U2OS Assay Protocol • Certificate of Analysis
Storage: The Tango™ CXCR7-bla U2OS cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.