A part of the PI3K/AKT Pathway, 4E-BP1 (EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1) is a cytosolic protein that is phosphorylated at Thr46 by mTORC1 upon stimulation of the pathway.
For use in combination with the GFP-4E-BP1 physiological protein substrate (PV4759) to evaluate inhibitors in medium to high throughput screening applications. An optimized mTor assay buffer (PV4794) is also available.
For Research Use Only. Not for use in diagnostic procedures.
사양
콘주게이트
Tb (Terbium)/GFP (EmGFP)
형식
384-well Plate
여기/방출
340⁄490, 520
반응성
Human
배송 조건
Dry Ice
판독
End Point
반응성 약어
Hu
타겟 효소
Serine⁄Threonine Kinases
기술
TR-FRET
검증된 키나아제
FRAP1 (mTOR), FRAP1 (mTOR)
제품라인
LanthaScreen™
구성 및 보관
Terbium-labeled anti-4E-BP1 [pThr46] antibody in HEPES buffered saline. Store at -20°C.