Fluorescein-ERM (LRRKtide)

A fluorescein-labeled peptide substrate based upon ezrin/radixin/moesin (ERM) that is phosphorylated by LRRK2 and LRRK2 mutants.For use in combination with자세히 알아보기

카탈로그 번호	수량
PV4901	1 mg

카탈로그 번호 PV4901

제품 가격(KRW)

A fluorescein-labeled peptide substrate based upon ezrin/radixin/moesin (ERM) that is phosphorylated by LRRK2 and LRRK2 mutants.

For use in combination with the LanthaScreen™ Tb-anti-ERM (pLRRKtide) Antibody (PV4899) to evalute inhibitors in medium to high throughput screening applications.

For Research Use Only. Not for use in diagnostic procedures.

아미노산 서열Fluorescein-GAGRLGRDKYKTLRQIRQ

어세이 입력Biochemical terbium phospho-specific activity

유전자 ID(Entrez)120892

라벨 또는 염료FITC (Fluorescein)

분자량2475.8 Da

수량1 mg

배송 조건Dry Ice

기질ERM (LRRKtide)

타겟 입력LRRK2 D1994A, LRRK2 R1441C, LRRK2 I2020T, LRRK2 G2019S, LRRK2

검증된 키나아제LRRK2

검출 방법Fluorescence

Substrate PropertiesPeptide-Based Substrate

기질 유형Kinase Substrate

Target EnzymeSerine/Threonine Kinases

Unit SizeEach

구성 및 보관

400 μM Fluorescein-ERM (LRRKtide) peptide substrate in water. Store at -20°C and protect from light.

인용 및 참조 문헌 (1)

인용 및 참조 문헌

Abstract

Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.

Authors:Anand VS, Reichling LJ, Lipinski K, Stochaj W, Duan W, Kelleher K, Pungaliya P, Brown EL, Reinhart PH, Somberg R, Hirst WD, Riddle SM, Steven P B,

Journal:FEBS J

PubMed ID:19076219

Mutations in leucine-rich repeat kinase 2 (LRRK2) comprise the leading cause of autosomal dominant Parkinson's disease, with age of onset and symptoms identical to those of idiopathic forms of the disorder. Several of these pathogenic mutations are thought to affect its kinase activity, so understanding the roles of LRRK2, and ... More