ERM (LRRKtide) Substrate
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인용 및 참조 문헌 (1)

ERM (LRRKtide) Substrate

A peptide substrate based upon ezrin/radixin/moesin (ERM) that is phosphorylated by LRRK2 and LRRK2 mutants. For use with the Adapta™자세히 알아보기
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카탈로그 번호수량
PV50931 mL
카탈로그 번호 PV5093
제품 가격(KRW)
1,524,000
Each
카트에 추가하기
수량:
1 mL
제품 가격(KRW)
1,524,000
Each
카트에 추가하기
A peptide substrate based upon ezrin/radixin/moesin (ERM) that is phosphorylated by LRRK2 and LRRK2 mutants. For use with the Adapta™ Universal Kinase Assay (PV5099).
For Research Use Only. Not for use in diagnostic procedures.
사양
아미노산 서열RLGRDKYKTLRQIRQ
어세이 입력Biochemical ADP accumulation
유전자 ID(Entrez)120892
분자량1931.2 Da
수량1 mL
배송 조건Dry Ice
기질peptide based upon ezrin/radixin/moesin (ERM)
타겟 입력LRRK2 G2019S, LRRK2
검증된 키나아제LRRK2
검출 방법Fluorescence
Substrate PropertiesPeptide-Based Substrate
기질 유형Kinase Substrate
Target EnzymeSerine/Threonine Kinases
Unit SizeEach
구성 및 보관
2 mM ERM (LRRKtide) peptide substrate in 50 mM HEPES (pH 7.5), 0.01% Brij-35, 10 mM MgCl2 and 1 mM EGTA. Store at -20°C.

인용 및 참조 문헌 (1)

인용 및 참조 문헌
Abstract
Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.
Authors:Anand VS, Reichling LJ, Lipinski K, Stochaj W, Duan W, Kelleher K, Pungaliya P, Brown EL, Reinhart PH, Somberg R, Hirst WD, Riddle SM, Steven P B,
Journal:FEBS J
PubMed ID:19076219
Mutations in leucine-rich repeat kinase 2 (LRRK2) comprise the leading cause of autosomal dominant Parkinson's disease, with age of onset and symptoms identical to those of idiopathic forms of the disorder. Several of these pathogenic mutations are thought to affect its kinase activity, so understanding the roles of LRRK2, and ... More