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인용 및 참조 문헌 (163)
Invitrogen™
Succinimidyl 3-(2-Pyridyldithio)Propionate (SPDP)
The heterobifunctional, crossslinker succinimidyl 3-(2-pyridyldithio)propionate (SPDP) enables one to covalently link two target groups. The succinimidyl ester chemically reacts with자세히 알아보기
| 카탈로그 번호 | 수량 |
|---|---|
| S1531 | 100 mg |
카탈로그 번호 S1531
제품 가격(KRW)
465,000
キャンペーン価格
Ends: 31-Dec-2025
546,000할인액 81,000 (15%)
Each
수량:
100 mg
제품 가격(KRW)
465,000
キャンペーン価格
Ends: 31-Dec-2025
546,000할인액 81,000 (15%)
Each
The heterobifunctional, crossslinker succinimidyl 3-(2-pyridyldithio)propionate (SPDP) enables one to covalently link two target groups. The succinimidyl ester chemically reacts with primary amines and after mild reduction of the dithiol, it can react form a disulfide with other thiols. Crosslinking reagents are useful for probing the spatial relationships and interactions within and between biomolecules.
For Research Use Only. Not for use in diagnostic procedures.
사양
세포 투과성Yes
설명SPDP
형태Solid
라벨링 방법Chemical Labeling
분자량312.36
페길레이티드No
수량100 mg
반응성 부분NHS Ester, Pyridyldisulfide
용해도DMF, DMSO
스페이서 암 길이6.8 Å
수용성No
화학물질 반응성Amine-Sulfhydryl
CleavableBy Thiols
교차결합제 유형Heterobifunctional
형식Standard
제품 유형Crosslinker
스페이서Short (<10 Å)
Unit SizeEach
구성 및 보관
Upon receipt store at -20°C protected from light.
자주 묻는 질문(FAQ)
Can you provide the shelf-life for Succinimidyl 3-(2-Pyridyldithio)Propionate (SPDP)?
인용 및 참조 문헌 (163)
인용 및 참조 문헌
Abstract
Blockade of the galactose-binding sites of ricin by its linkage to antibody. Specific cytotoxic effects of the conjugates.
Journal:European journal of biochemistry
PubMed ID:6608447
A method is described for preparing specific cytotoxic agents by linking intact ricin to antibodies in a manner that produces obstruction of the galactose-binding sites on the B chain of the toxin and so diminishes the capacity of the conjugate to bind non-specifically to cells. The conjugates were synthesised by
Enhancement of the thrombolytic potency of plasminogen activators by conjugation with clot-specific monoclonal antibodies.
Journal:Bioconjug Chem
PubMed ID:1790167
Detection of one attomole of [Arg8]-vasopressin by novel noncompetitive enzyme immunoassay (hetero-two-site complex transfer enzyme immunoassay).
Journal:J Biochem (Tokyo)
PubMed ID:1778973
'One attomole of [Arg8]-vasopressin (AVP) was detected by a novel noncompetitive enzyme immunoassay (hetero-two-site complex transfer enzyme immunoassay). AVP was indirectly biotinylated using N-hydroxysuccinimidobiotin and trapped onto an anti-AVP IgG-coated polystyrene ball. After washing, biotinylated AVP was eluted from the polystyrene ball with HCl and was reacted with 2,4-dinitrophenyl-fluorescein disulfide-bovine
Activation of methotrexate-alpha-alanine by carboxypeptidase A-monoclonal antibody conjugate.
Journal:Biochemistry
PubMed ID:1731945
'Carboxypeptidase A (CP-A) and monoclonal antibody KS1/4 directed against an antigen on human lung adenocarcinoma cells (UCLA-P3) were derivatized by treatment with succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate and N-succinimidyl 3-(2-pyridyldithio)propionate, respectively. The derivatized proteins were reacted to produce thioether-linked enzyme-antibody conjugates. Sequential HPLC size-exclusion and DEAE chromatography separated the conjugate preparation from unreacted
Selective destruction of nerve growth factor receptor-bearing cells in vitro using a hybrid toxin composed of ricin A chain and a monoclonal antibody against the nerve growth factor receptor.
Journal:J Cell Biol
PubMed ID:2993314
'A hybrid toxin composed of ricin A chain and a monoclonal antibody directed against the rat nerve growth factor (NGF) receptor (192-IgG) was prepared using the heterobifunctional cross-linking agent N-succinimidyl-3-(2-pyridyldithio)-propionate and purified by affinity chromatography. Characterization studies showed that the hybrid, 192-s-s-A, displaced bound 125I-labeled 192-IgG from rat superior cervical