JC-1 Dye (Mitochondrial Membrane Potential Probe)

인용 및 참조 문헌 (400)

Invitrogen™

JC-1 Dye (Mitochondrial Membrane Potential Probe)

JC-1는 미토콘드리아에 축적되는 새로운 catonic carbocyanine 염료입니다. 이 염료는 저농도 monomer로 존재하고 fluorescein처럼 녹색 형광을 발합니다. 높은 농도에서는 염료가 J-aggregate를자세히 알아보기

카탈로그 번호	수량
T3168	5 mg

카탈로그 번호 T3168

제품 가격(KRW)

919,000

キャンペーン価格

Ends: 31-Dec-2025

967,000

할인액 48,000 (5%)

카트에 추가하기

제품 가격(KRW)

919,000

キャンペーン価格

Ends: 31-Dec-2025

967,000

할인액 48,000 (5%)

카트에 추가하기

JC-1는 미토콘드리아에 축적되는 새로운 catonic carbocyanine 염료입니다. 이 염료는 저농도 monomer로 존재하고 fluorescein처럼 녹색 형광을 발합니다. 높은 농도에서는 염료가 J-aggregate를 형성해 폭넓은 여기 스펙트럼과 ∼590 nm에서 최대 방출을 나타냅니다. 이런 특징으로 JC-1가 미토콘드리아 막 전위에 민감한 표지자가 되는 것입니다. 비슷한 특징을 가진 다른 염료로 JC-9 (D-22421)가 있습니다.

For Research Use Only. Not for use in diagnostic procedures.

검출 방법Fluorescence

수량5 mg

배송 조건Room Temperature

세포하위구조 국지화Mitochondria

색상Green

용도 (장비)Fluorescence Microscope, Flow Cytometer

제품 유형Dye

Unit Size5 mg

구성 및 보관

Store at room temperature and protect from light.

자주 묻는 질문(FAQ)

I am seeing high background outside of my neuronal cells when using membrane potential indicators. What can I do to reduce background?

If you use our FluoVolt Membrane Potential Kit (Cat. No. F10488), the kit provides a background suppressor to reduce this problem. For other indicators, consider the use of BackDrop Background Suppressor (Cat no. R37603, B10511, and B10512).

Find additional tips, troubleshooting help, and resources within our Cell Analysis Support Center.

What is the difference between fast and slow-response membrane potential probes?

Molecules that change their structure in response to the surrounding electric field can function as fast-response probes for the detection of transient (millisecond) potential changes. Slow-response dyes function by entering depolarized cells and binding to proteins or membranes. Increased depolarization results in additional dye influx and an increase in fluorescence, while hyperpolarization is indicated by a decrease in fluorescence. Fast-response probes are commonly used to image electrical activity from intact heart tissues or measure membrane potential changes in response to pharmacological stimuli. Slow-responding probes are often used to explore mitochondrial function and cell viability.

Find additional tips, troubleshooting help, and resources within our Cell Analysis Support Center.

What type of membrane potential indicators do you offer and how should I choose one for my experiment?

A membrane potential indicator selection guide can be found here (https://www.thermofisher.com/us/en/home/life-science/cell-analysis/cell-viability-and-regulation/ion-indicators/membrane-potential-indicators.html).

Find additional tips, troubleshooting help, and resources within our Cell Analysis Support Center.

인용 및 참조 문헌 (400)

인용 및 참조 문헌

Abstract

Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramides production.

Authors:Embade N,Valerón PF,Aznar S,López-Collazo E,Lacal JC

Journal:Molecular biology of the cell

PubMed ID:11102528

Rho proteins, members of the Ras superfamily of GTPases, are critical elements in signal transduction pathways governing cell proliferation and cell death. Different members of the family of human Rho GTPases, including RhoA, RhoC, and Rac1, participate in the regulation of apoptosis in response to cytokines and serum deprivation in ... More

Large-scale chemical dissection of mitochondrial function.

Authors:Wagner BK,Kitami T,Gilbert TJ,Peck D,Ramanathan A,Schreiber SL,Golub TR,Mootha VK

Journal:Nature biotechnology

PubMed ID:18297058

Mitochondrial oxidative phosphorylation (OXPHOS) is central to physiology and disease pathogenesis. To systematically investigate its activity and regulation, we performed a wide range of assays of OXPHOS physiology and nuclear and mitochondrial gene expression across 2490 chemical perturbations in muscle cells. Through mining of the resulting compendium, we discovered that: ... More

Authors:

Journal:

PubMed ID:10891486

Mitochondria--potential role in cell life and death.

Authors:Griffiths EJ

Journal:Cardiovascular research

PubMed ID:10727650

The mitochondrial death/life regulator in apoptosis and necrosis.

Authors:Kroemer G,Dallaporta B,Resche-Rigon M

Journal:Annual review of physiology

PubMed ID:9558479

Both physiological cell death (apoptosis) and, in some cases, accidental cell death (necrosis) involve a two-step process. At a first level, numerous physiological and some pathological stimuli trigger an increase in mitochondrial membrane permeability. The mitochondria release apoptogenic factors through the outer membrane and dissipate the electrochemical gradient of the ... More

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