Thapsigargin
Thapsigargin
인용 및 참조 문헌 (508)
Invitrogen™

Thapsigargin

Thapsigargin is a naturally occurring sesquiterpene lactone isolated from the umbelliferous plant Thapsia garganica. This tumor promoter releases Ca2+ from자세히 알아보기
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카탈로그 번호수량
T74581 mg
T745920 x 50 μg
카탈로그 번호 T7458
제품 가격(KRW)
247,000
온라인 행사
Ends: 31-Dec-2025
274,000
할인액 27,000 (10%)
1 mg
카트에 추가하기
수량:
1 mg
제품 가격(KRW)
247,000
온라인 행사
Ends: 31-Dec-2025
274,000
할인액 27,000 (10%)
1 mg
카트에 추가하기
Thapsigargin is a naturally occurring sesquiterpene lactone isolated from the umbelliferous plant Thapsia garganica. This tumor promoter releases Ca2+ from intracellular stores by specifically inhibiting the endoplasmic reticulum Ca2+-ATPase; it does not directly affect plasma membrane Ca2+-ATPases, Ins 1,4,5-P3 production or protein kinase C activity. Thapsigargin is also available in a 1 mg packaging, T7458.
For Research Use Only. Not for use in diagnostic procedures.
사양
라벨 유형Unlabeled
분자식C34H50O12
수량1 mg
권장 스토리지Store in freezer (-5°C to -30°C)
배송 조건Room Temperature
물리적 형태Solid
제품 유형Inhibitor
Unit Size1 mg

인용 및 참조 문헌 (508)

인용 및 참조 문헌
Abstract
Calcium signaling.
Authors:Clapham DE
Journal:Cell
PubMed ID:7834745
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.
Authors:Thastrup O, Cullen PJ, Drøbak BK, Hanley MR, Dawson AP
Journal:Proc Natl Acad Sci U S A
PubMed ID:2138778
Thapsigargin, a tumor-promoting sesquiterpene lactone, discharges intracellular Ca2+ in rat hepatocytes, as it does in many vertebrate cell types. It appears to act intracellularly, as incubation of isolated rat liver microsomes with thapsigargin induces a rapid, dose-dependent release of stored Ca2+. The thapsigargin-releasable pool of microsomal Ca2+ includes the pools ... More
Muscarinic receptors modulate intracellular Ca(2+) concentration in hyaline cells of the chicken basilar papilla.
Authors:Lippe WR, Zirpel L, Stone JS
Journal:J Comp Physiol A Neuroethol Sens Neural Behav Physiol
PubMed ID:12073083
Nonsensory hyaline cells border the sensory epithelium of the auditory end-organ (basilar papilla) in birds and reptiles. Their innervation by cochlear cholinergic efferent fibers and the presence of contractile proteins suggest that hyaline cells may actively regulate basilar membrane mechanics. The cholinergic pharmacology of hyaline cells was studied by measuring ... More
Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease.
Authors:Hori O, Ichinoda F, Tamatani T, Yamaguchi A, Sato N, Ozawa K, Kitao Y, Miyazaki M, Harding HP, Ron D, Tohyama M, M Stern D, Ogawa S
Journal:J Cell Biol
PubMed ID:12082077
'The rat homologue of a mitochondrial ATP-dependent protease Lon was cloned from cultured astrocytes exposed to hypoxia. Expression of Lon was enhanced in vitro by hypoxia or ER stress, and in vivo by brain ischemia. These observations suggested that changes in nuclear gene expression (Lon) triggered by ER stress had ... More
Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response.
Authors:Kokame K, Kato H, Miyata T
Journal:J Biol Chem
PubMed ID:11112790
'Herp is a 54-kDa membrane protein in the endoplasmic reticulum (ER). The mRNA expression level of Herp is increased by the accumulation of unfolded proteins in the ER. Transcriptional changes designed to deal with this type of ER stress is called the unfolded protein response (UPR). Most mammalian UPR-target genes ... More
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