Orbitrap™ Tribrid™ Apex Mass Spectrometers

Performance, versatility, and useability to help you unlock deeper insights faster and achieve exceptional sensitivity, throughput, and confidence in every experiment. Designed with your workflows in mind, Orbitrap Tribrid Apex Mass Spectrometers combine advanced fragmentation, ion parallelization, flexible MSⁿ workflows, intelligent acquisition strategies, and streamlined usability to generate high-quality data with ease. Deconvolute complex biopharmaceuticals and protein structures with alternative fragmentation and single-ion detection to characterize small molecule structures with improved speed and sensitivity, powered by intelligent acquisition.

To enhance workflows from proteomics to pharma, four fit-for-purpose Editions tailored for MultiOmics, Structural Biology, BioPharma, and Small Molecule applications deliver improved scan speed and ion parallelization.

• Native MS option*: For improved selectivity and MSⁿ sensitivity of macromolecules, extend Orbitrap mass range up to m/z 16000 in MS1 and m/z 20,000 in MS2 and new quadrupole isolation up to mz 12,000.
• PTCR option*: Reduce mz spectrum complexity to enhance proteoform characterization at MS1 and MS2 levels.
• UV-laser option: Alternative fragmentation for top-down proteomics, oligonucleotides, lipidomics, and other analytes.
• IR-laser option: Maintain native structures with desolvation. Improve fragmentation of TMT reporter ions, top-down MS, and peptides.
• Direct Mass Technology mode option*: Single-ion detection for charge assignment without isotope or charge state patterns, enabling complex analytes to be elucidated for identification and characterization.
• Easy-ETD option*: Achieve high sequence coverage of proteins, including site localization of labile PTMs.
• EASY-IC ion source option*: Obtain sub-1ppm mass accuracy with internal calibration.
• Dual IRMs: Confidently identify more molecules with two ion-routing multiples to increase scan rate and sensitivity.
• Real-Time Library Search: High confidence identifications for peptide or small molecule analysis using MSⁿ.
• Auto-Ready 2 ion source: Spend less time on system setup with a dedicated source for autocalibration.
• Pre-built method templates: Optimized methods to cover diverse applications.
• Environmentally friendly, oil-free dry pump is standard: Decrease maintenance while providing leak-free vacuum performance.

*Features only available on MultiOmics, Structural Biology, and BioPharma Editions.