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Espectrómetro de masas Orbitrap Ascend Tribrid
Espectrómetro de masas Orbitrap Ascend Tribrid
Espectrómetro de masas Orbitrap Ascend Tribrid
Espectrómetro de masas Orbitrap Ascend Tribrid
Thermo Scientific™

Espectrómetro de masas Orbitrap Ascend Tribrid

Amplíe su ciencia para la proteómica y el análisis de proteínas nativas, con versatilidad y facilidad de uso utilizando el espectrómetro de masas Thermo Scientific Orbitrap Ascend Tribrid.

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Número de catálogoModelo
B51003847Orbitrap Ascend MultiOmics Tribrid MS
FSN06-10000Orbitrap Ascend Tribrid MS
B51003848Orbitrap Ascend Structural Biology Tribrid MS
B51003849Orbitrap Ascend BioPharma Tribrid MS
Número de catálogo B51003847
Precio (MXN)
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Modelo:
Orbitrap Ascend MultiOmics Tribrid MS

Exceed experimental expectation and versatility with recommended MultiOmics, Structural Biology, and BioPharma configurations of the Thermo Scientific™ Orbitrap Ascend Editions Tribrid™ Mass Spectrometer. Each Edition provides a tailored configuration of options for each application space, simplifying your decisions and streamlining your research. Characterize even the largest biopharmaceuticals and protein complexes with the Native MS option, which extends the Orbitrap mass range up to m/z 16,000 and new quadrupole isolation up to m/z 8,000. Unlock the potential of alternate fragmentation techniques to decipher the most challenging molecules.

Con su versatilidad integrada, rendimiento líder y capacidades de MSn , Orbitrap Ascend Tribrid MS produce datos de alta calidad con facilidad, lo que le permite abordar analitos desafiantes necesarios para ampliar su ciencia. En conjunto, estas funciones hacen que este instrumento sea especialmente adecuado para la proteómica de células individuales y de alto rendimiento, la caracterización de mezclas complejas de proteínas o productos farmacéuticos basados en moléculas pequeñas y el descifrado de estructuras proteicas de orden superior.

  • Opción de intervalo de masa extendido hasta 16 000 m/z: Analice macromoléculas y nuevas modalidades mientras mejora la detección y la sensibilidad
  • IRM dobles: Identifique con confianza más proteoma con dos múltiplos de enrutamiento de iones (IRM) para aumentar la velocidad de escaneo y la sensibilidad
  • Fuente iónica Auto-Ready: Dedique más tiempo a los resultados y menos tiempo a la configuración del instrumento con una nueva fuente dedicada para la calibración automática
  • Búsqueda de bibliotecas en tiempo real: Proporciona identificaciones de mayor confianza, ahora tanto para péptidos como para análisis de moléculas pequeñas utilizando datos de MSn
  • Flujos de trabajo de adquisición de datos Thermo Scientific AcquireX: Mayor cobertura para el análisis de moléculas pequeñas
  • Opción UVPD: Fragmentación mejorada para proteómica de arriba hacia abajo, oligonucleótidos, lipidómica y otros analitos
  • Opción PTCR: Capacidades adicionales para analizar proteoformas
  • Opción Easy-ETD: Los fragmentos multiplican precursores cargados incluidos los PTM
  • Opción de fuente de iones EASY-IC: Precisión de masa inferior a 1 ppm con calibración interna
  • Software de control de instrumentos con plantillas de métodos optimizados y preconstruidos para diversas aplicaciones
Especificaciones
Dimensiones (Pr x An x Al)32 x 50 x 28 in (81 x 127 x 70 cm)
Intervalo dinámico> 5000 within a single scan
Exactitud de masa< 3 ppm RMS using external calibration
ModeloOrbitrap Ascend MultiOmics Tribrid MS
Cambio de polaridadOne full experimental cycle acquired in < 1.1 seconds
Velocidades de barridoHasta 45 Hz
Peso (métrico)181 kg (400 lb)
Intervalo de masas40 to 6000 m/z
Max. ResolutionUp to 480,000 at m/z 200
TipoLC-MS Orbitrap
Unit SizeEach

Preguntas frecuentes

For labs focused on sensitivity, low-input samples, or PTM/complex proteomics, what performance improvements can they expect with Orbitrap Ascend Tribrid MS over previous instruments?

The Orbitrap Ascend Tribrid MS achieves ~20% higher phosphoproteome coverage compared to the previous Orbitrap Eclipse Tribrid MS (under matched conditions) and showed ~25% improvement in PTM site localization accuracy. The improved ion optics and increased acquisition rates translate directly into more identifications per unit time—for example, in a TMTpro 18-plex experiment the Orbitrap Ascend Tribrid quantified >8,000 proteins in less than 9 hours (a ~30% reduction in time compared to the previous instrument). For low-input workflows, the improved ion transmission and flexibility in fragmentation make the system especially well positioned for challenging samples.

What advanced acquisition modes or intelligent software features are standard to the Orbitrap Ascend Tribrid MS that improve productivity and data quality?

The Orbitrap Ascend Tribrid MS includes intelligent acquisition and control features such as Real-Time Search (RTS) and Real-Time Library Search (RTLS) to trigger MS/MS or MSⁿ events based on library matches or spectral patterns. It also offers method templates optimized for workflows (called “pre-built optimized templates”) and the Auto-Ready ion source for automated calibration without manual intervention. These features help reduce setup time, improve reproducibility, and offer higher throughput and reliability than many older systems.

Why would I choose an Orbitrap Ascend Tribrid MS for multi-omics and biopharmaceutical workflows over specialized single-domain systems?

The MultiOmics, BioPharma, and Structural Biology Editions of the Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer provide tailored hardware and software to the unique application space. For example, to enable native protein complex and biotherapeutic characterization, the Native MS option supports mass detection up to m/z 16,000 and quadrupole isolation up to m/z 8,000. At the same time, for multiomics (metabolomics, lipidomics, proteomics) it supports high-throughput multiplexed TMT workflows (e.g., TMTpro 32-plex) and advanced fragmentation, including ETD and UVPD.

What are the main architecture and performance advantages of the Orbitrap Ascend Tribrid MS compared to earlier Tribrid or HRAM systems?

The Orbitrap Ascend Tribrid MS features a unique Tribrid architecture (quadrupole → dual-pressure linear ion trap → Orbitrap mass analyzer) and incorporates several hardware innovations: a high-capacity transfer tube and modified electrodynamic ion funnel for increased ion flux; a segmented “QR5” quadrupole with hyperbolic surfaces for improved ion transmission; dual Ion Routing Multipoles for better capture and dissociation of ions.

Compared with prior-generation Tribrid systems, the Orbitrap Ascend Trbrid delivers higher acquisition rates (e.g., up to ~45 Hz at 7,500 resolution in the Orbitrap; up to ~50 Hz in the ion trap) and improved sensitivity for labile compounds. These capabilities make it more versatile and higher-performing than many conventional HRAM or single-analyzer systems.