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Citas y referencias (33)
Invitrogen™
DiFMUP (6,8-Difluoro-4-Methylumbelliferyl Phosphate)
El DiFMUP es un derivado fluorado de 4-más del 90 fosfato (MUP) que tiene un menor pKa que el deMás información
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| Número de catálogo | Cantidad |
|---|---|
| D6567 | 5mg |
| D22065 | 10 x 10mg |
Número de catálogo D6567
Precio (MXN)
-
Cantidad:
5mg
El DiFMUP es un derivado fluorado de 4-más del 90 fosfato (MUP) que tiene un menor pKa que el de MUP, lo que convierte al DiFMUP en un sustrato excelente para el análisis continuo de fosfatasas ácidas a pH bajo. El producto reactivo de DiFMUP posee una excitación/emisión máxima de ∼ 358/450 nm. El DiFMUP también está disponible en diez viales de 10 mg cada uno (D-22065).
Para uso exclusivo en investigación. No apto para uso en procedimientos diagnósticos.
Especificaciones
ColorAzul
Excitación/emisión358⁄455
Para utilizar con (equipo)Lector de microplacas
Etiqueta o tinteDiFMU
Cantidad5mg
Condiciones de envíoTemperatura ambiente
SustratoSustrato de fosfatasa
Método de detecciónFluorescente
FormularioPolvo
Substrate PropertiesSustrato químico
Target EnzymeFosfatasas
Unit SizeEach
Contenido y almacenamiento
Almacenar en congelador (de - 5 a - 30 °C).
Citations & References (33)
Citations & References
Abstract
Surface phosphophilicity of aluminum-containing adjuvants probed by their efficiency for catalyzing the P--O bond cleavage with chromogenic and fluorogenic substrates.
Journal:Anal Biochem
PubMed ID:11476547
'Aluminum-containing adjuvants are widely used in a variety of vaccine products, such as recombinant proteins, virus-like particles, conjugated polysaccharides, and recently DNA vaccines. Aluminum-containing adjuvants are also known to have a high affinity to inorganic phosphate and its mono- or diesters. Since phosphate groups are present in many antigens as
Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP.
Journal:Nat Cell Biol
PubMed ID:15592458
'Integrin-mediated cell adhesion regulates a multitude of cellular responses, including proliferation, survival and cross-talk between different cellular signalling pathways. So far, integrins have been mainly shown to convey permissive signals enabling anchorage-dependent receptor tyrosine kinase signalling. Here we show that a collagen-binding integrin alpha(1)beta(1) functions as a negative regulator of
Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.
Journal:Mol Pharmacol
PubMed ID:16717135
'Shp2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene. It is involved in growth factorinduced activation of mitogen-activated protein (MAP) kinases Erk1 and Erk2 (Erk1/2) and has been implicated in the pathogenicity of the oncogenic bacterium Helicobacter pylori. Moreover, gain-of-function Shp2 mutations have been found in
Loss of phosphatase activity in Ptp69D alleles supporting axon guidance defects.
Journal:J Cell Biochem
PubMed ID:16514605
'PTP69D is a receptor protein tyrosine phosphatase that was identified as a key regulator of neuromuscular axon guidance in Drosophila, and has subsequently been shown to play a similar role in the central nervous system and retina. Three Ptp69D alleles with mutations involving catalytically important residues exhibit a high degree
High yield expression of serine/threonine protein phosphatase type 5, and a fluorescent assay suitable for use in the detection of catalytic inhibitors.
Journal:Assay Drug Dev Technol
PubMed ID:17939754
'Protein phosphatase type 5 (PP5) belongs to the PPP family of serine/threonine protein phosphatases and is expressed in most, if not all, human tissues. Although the physiological roles played by PP5 are not yet clear, PP5 is found in association with several proteins that influence intracellular signaling networks initiated by