QuantiGene™ Plex Human ADMETOX Panel, 80-plex

The QuantiGene Plex Human ADMETOX Panel, 80-plex, enables the measurement of gene expression of all relevant ADME (absorption, distribution, metabolism, and excretion) and toxicological biomarkers through the analysis of 80 RNA targets in a single well using Luminex xMAP technology in combination with branched DNA signal amplification. Analyze 80 genetic targets implicated in drug metabolism, including enzymes, transporters, and CYPs, as well as toxicology and apoptosis for efficient profiling of your drug discovery and basic research samples.

QuantiGene Plex panels are extensively tested for target combinability, interference, and cross-reactivity to provide the highest level of validation and precision. This kit is not compatible with the MAGPIX instrument.

This panel is used in combination with the QuantiGene Plex Gene Expression Assay Ordering.

Features of the QuantiGene Plex Human ADMETOX Panel, 80-plex, include:

• True multiplexing—measure 80 genes of interest and housekeeping genes in the same well with no cross-reactivity
• Accommodation of difficult sample types—works with degraded and cross-linked RNA in FFPE tissues and blood
• Standardized platform—uses 96-well plate format compatible with Luminex 200, FLEXMAP 3D, and INTELLIFLEX systems (384-well format available on demand)
• Simple workflow—employs an ELISA-like workflow with direct hybridization of transcripts to beads and transcript labeling (branched DNA signal amplification and PE readout)
• Customize with validated targets—if alternative targets are needed in this panel, select from our large inventory of over 22,000 genes to QuantiGene Plex data analysis app.

  Applications

  QuantiGene Plex assay research applications include compound screening of drug candidates, biomarker verification, siRNA knockdown efficiency, prospective and/or retrospective analysis of clinical samples, microarray validation, predictive toxicology, and detection of translocations and fusion genes. In general, any multiplex gene expression analysis can be done with QuantiGene Plex assays, independent of species or sample type.